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Invitrogen
FNTA Polyclonal Antibody
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Product Details
PA1-41328
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Chicken,
Human,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 150-250 of human farnesyltransferase.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
PBS with 0.2% gelatin
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: mouse colon cell lysate.
Cross reacts with Chimpanzee. Predicted to cross react with Mouse.
Target Information
FNTA (Farnesyltransferase, CAAX box; alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/ geranyl geranyl transferase type I alpha subunit(PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit) is located locus 8p11 (human). Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The best characterized among these prenyltransferases is the CAAX farnesyl transferase (2. 5. 1. 21), which is alpha-beta heterodimeric enzyme. It catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box. FNTA or the alpha subunit of farnesyl transferase is shared by the geranyl-geranyl protein transferases. Apart from transfer of farnesyl and geranyl groups to proteins, FNTA has been proposed to regulate intracellular signaling pathways involving p21ras. Reports have shown that FNTA interacts with TGF-beta and activin-type I receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAAX farnesyltransferase subunit alpha; farnesyl-protein transferase alpha-subunit; Farnesyltransferase, subunit alpha; FTase-alpha; GGTase-I-alpha; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; protein prenyltransferase alpha subunit repeat containing 2; Ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase alpha subunit; Type I protein geranyl-geranyltransferase subunit alpha
Gene Aliases: FNTA; FPTA; PFAS; PGGT1A; PTAR2
UniProt ID: (Human) P49354, (Rat) Q04631
Entrez Gene ID: (Chicken) 427299, (Dog) 475566, (Human) 2339, (Rat) 25318
protein farnesyltransferase activity
protein geranylgeranyltransferase activity
CAAX-protein geranylgeranyltransferase activity
Rab geranylgeranyltransferase activity
protein binding
microtubule binding
acetylcholine receptor regulator activity
receptor tyrosine kinase binding
alpha-tubulin binding
drug binding
zinc ion binding
isoprenoid binding
peptide binding
acyltransferase
viral or transposable element protein
cellular component disassembly involved in execution phase of apoptosis
transforming growth factor beta receptor signaling pathway
protein farnesylation
protein geranylgeranylation
regulation of rhodopsin mediated signaling pathway
neurotransmitter receptor metabolic process
skeletal muscle acetylcholine-gated channel clustering
positive regulation of tubulin deacetylation
positive regulation of deacetylase activity
regulation of neurotransmitter receptor activity
positive regulation of cell proliferation
response to inorganic substance
regulation of receptor activity
response to organic cyclic compound
response to cytokine
negative regulation of apoptotic process
positive regulation of cell cycle
positive regulation of nitric-oxide synthase biosynthetic process
negative regulation of nitric-oxide synthase biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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