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Invitrogen
FREM2 Polyclonal Antibody
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产品信息
PA5-120413
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 47-300 of human FREM2 (NP_997244.4).
偶联物
形式
Liquid
浓度
1.43 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: Jurkat, HepG2, 293T. The target is usually found in the following locations: Cell membrane, Extracellular side, Single-pass type I membrane protein.
Immunogen sequence: QPAAFGRALL SPGLAGAAGV PAEEAIVLAN RGLRVPFGRE VWLDPLHDLV LQVQPGDRCA VSVLDNDALA QRPGRLSPKR FPCDFGPGEV RYSHLGARSP SRDRVRLQLR YDAPGGAVVL PLVLEVEVVF TQLEVVTRNL PLVVEELLGT SNALDARSLE FAFQPETEEC RVGILSGLGA LPRYGELLHY PQVPGGAREG GAPETLLMDC KAFQELGVRY RHTAASRSPN RDWIPMVVEL RSRGAPVGSP ALKR
靶标信息
FREM2 is a member of the FRAS1-related extracellular matrix protein family and like FREM1, mutations in the FREM2 gene are associated with Fraser syndrome. FREM2 localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes and is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The FREM2 gene is one of several genes whose transcription is affecteded by TFAP2C, a transcription factor involved in mammary development, differentiation, and oncogenesis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ECM3 homolog; FRAS1-related extracellular matrix protein 2; NV domain containing protein NV1; NV domain-containing protein 1
基因别名: 6030440P17Rik; 8430406N05Rik; b2b1562Clo; FREM2; Gm409; my; ne; Nv1
UniProt ID: (Human) Q5SZK8, (Mouse) Q6NVD0
Entrez Gene ID: (Human) 341640, (Mouse) 242022
