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Invitrogen
FosB Polyclonal Antibody
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FosB Antibody (PA5-79280) in IHC (P)
Immunohistochemical analysis of FOSB in paraffin-embedded section of human renal cancer tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution).The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/mL rabbit anti-FOSB antibody (Product # PA5-79280) overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as se... View More
产品信息
PA5-79280
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human Fos B (264-291aa LPFQTSQDAPPNLTASLFTHSEVQVLGD).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat thymus tissue, mouse thymus tissue, mouse ovary tissue, mouse spleen tissue, mouse kidney tissue, mouse RAW2467 whole cell, human HL-60 whole cell, human THP-1 whole cell. IHC: human renal cancer tissue, human placenta tissue, mouse intestine tissue, rat intestine tissue. Flow: SiHa cell.
靶标信息
c-FOS is a nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. It has a critical function in regulating the development of cells destined to form and maintain the skeleton, and is thought to have an important role in signal transduction, cell proliferation and differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activator protein 1; DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; FBJ osteosarcoma oncogene B; FBJ osteosarcoma viral oncogene isoform deltaFosb-2; fos b; FosB proto-oncogene, AP-1 trancription factor subunit; FosB proto-oncogene, AP-1 transcription factor subunit; G0/G1 switch regulatory protein 3; MGC42291; oncogene FOS-B; Protein FosB; Transcription factor AP-1 subunit FosB
基因别名: AP-1; FOSB; fra-2; G0S3; GOS3; GOSB
UniProt ID: (Human) P53539, (Rat) D3ZLB7, (Mouse) P13346
Entrez Gene ID: (Human) 2354, (Rat) 100360880, (Mouse) 14282
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor binding
RNA polymerase II regulatory region sequence-specific DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
protein heterodimerization activity
basic leucine zipper transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
female pregnancy
response to mechanical stimulus
response to progesterone
cellular response to hormone stimulus
response to drug
response to morphine
positive regulation of transcription from RNA polymerase II promoter
response to corticosterone
response to cAMP
cellular response to calcium ion
regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
regulation of transcription, DNA-templated
