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Immunogen sequence: RPHGDTAKKP IIGILMQKCR NKVMKNYGRY YIAASYVKYL ESAGARVVPV RLDLTEKDYE ILFKSINGIL FPGGSVDLRR SDYAKVAKIF YNLSIQSFDD GDYFPVWGTC LGFEELSLLI SGECLLTATD TVDVAMPLNF TGGQLHSRMF QNFPTELLLS LAVEPLTANF HKWSLSVKNF TMNEKLKKFF NVLTTNTDGK IEFIST; Positive Samples: HeLa, Mouse kidney; Cellular Location: Lysosome, Melanosome, extracellular space
Gamma-Glutamyl hydrolase (GGH) is a homodimeric protein that catalyzes the cleavage of the gamma-glutamyl chain of folylpoly-gamma-glutamyl substrates and is a central enzyme in folyl and antifolyl poly-gamma-glutamate metabolism. The activities of the baculovirus-expressed enzyme and the enzyme from HL-60 cells were similar on methotrexate polyglutamates. GGH is expressed in a variety of human tumors and correlates with poor prognosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Conjugase; FGPH; Folylpolyglutamate hydrolase; Gamma-Glu-X carboxypeptidase; Gamma-glutamyl hydrolase; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); GH
基因别名: gamma-GH; GGH; GH
UniProt ID: (Human) Q92820, (Mouse) Q9Z0L8
Entrez Gene ID: (Human) 8836, (Mouse) 14590
分子生物学功能: cysteine protease