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Percent identity with other species by BLAST analysis: Human (93%) Chimpanzee, Gorilla, Orangutan, Monkey, Mouse (87%) Gibbon, Galago, Marmoset, Rat, Bat, Hamster, Rabbit, Horse (80%).
GPR83, a 423 A.A protein, is an orphan member of GPCR protein family and is closely related to tachykinin and NPY receptors. It is a human homolog of mouse GIR protein and is exclusively expressed and selectively up-regulated in brain. It is a cell surface receptor protein consisting of a putative seven-transmembrane-domain. Reports suggest GPR83 might be involved in the regulation of immune tolerance mechanism by inducing peripheral generation of Foxp3+ Treg cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: G protein-coupled receptor 72; G-protein coupled receptor 72; G-protein coupled receptor 83; glucocorticoid induced receptor; Hcepto9; Jp05
基因别名: GIR; GPR72; GPR83; JP05; KIAA1540
UniProt ID: (Human) Q9P1Y8
Entrez Gene ID: (Human) 10888
分子生物学功能: G-protein coupled receptor