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Invitrogen
Gephyrin Polyclonal Antibody
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FIGURE: 1 / 2
Gephyrin Antibody (720218) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized PC-3 cells for detection of endogenous Gephyrin using anti-Gephyrin Rabbit Polyclonal Antibody (Product # 720218, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of Gephyrin protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). P... View More
Product Details
720218
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Protein corresponding to Human GEPHYRIN (aa 1-220)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Rat, Mouse and Chicken
Target Information
Gephyrin is a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gephyrin; unnamed protein product
Gene Aliases: 5730552E08Rik; AI662856; BC027112; C230040D23; GEPH; GPH; GPHN; GPHRYN; HKPX1; KIAA1385; MOCODC
UniProt ID: (Human) Q9NQX3, (Mouse) Q8BUV3
Entrez Gene ID: (Human) 10243, (Mouse) 268566
nucleotide binding
catalytic activity
receptor binding
protein binding
ATP binding
nitrate reductase activity
transferase activity
protein binding, bridging
identical protein binding
molybdopterin cofactor binding
metal ion binding
binding, bridging
molybdopterin adenylyltransferase activity
molybdopterin molybdotransferase activity
cytoskeletal protein binding
protein complex scaffold
protein homodimerization activity
Mo-molybdopterin cofactor biosynthetic process
synapse assembly
establishment of synaptic specificity at neuromuscular junction
response to metal ion
molybdopterin cofactor biosynthetic process
establishment of protein localization
synapse organization
synaptic transmission, GABAergic
glycine receptor clustering
protein localization to membrane
gamma-aminobutyric acid receptor clustering
neurotransmitter receptor localization to postsynaptic specialization membrane
metabolic process
molybdenum incorporation into molybdenum-molybdopterin complex
protein homooligomerization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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