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Invitrogen
Glutamine Synthetase Recombinant Rabbit Monoclonal Antibody (HL2283)
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Glutamine Synthetase Antibody (MA5-50474) in IHC (P)
Immunohistochemical analysis of Glutamine Synthetase using Glutamine Synthetase Recombinant Monoclonal Antibody (Product # MA5-50474) in Paraffin embedded mouse cerebellum and kidney tissue at a dilution of 1:100. For Antigen retrieval citrate buffer, pH 6.0, as used for 15 min.
产品信息
MA5-50474
产品规格
种属反应
Dog,
Cat,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2283
抗原
Full length of human Glutamine synthetase.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell proliferation-inducing protein 59; GLNA; Glutamate ammonia ligase; glutamate decarboxylase; Glutamate--ammonia ligase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase (glutamine synthetase); glutamine synthase; Glutamine synthetase; Glutamine synthetase (glutamate-ammonia ligase); glutamine synthetase 1; glutamine synthetase I; GS; Palmitoyltransferase GLUL; Proliferation inducing protein 43; proliferation-inducing protein 43
基因别名: GLNS; GLUL; GS; PIG43; PIG59
UniProt ID: (Dog) Q8HZM5, (Human) P15104, (Mouse) P15105, (Rat) P09606
Entrez Gene ID: (Dog) 403443, (Human) 2752, (Mouse) 14645, (Rat) 24957
glutamate-ammonia ligase activity
ATP binding
protein-cysteine S-palmitoyltransferase activity
identical protein binding
metal ion binding
magnesium ion binding
glutamate decarboxylase activity
protein binding
glutamate binding
manganese ion binding
dynein light chain binding
nucleotide binding
catalytic activity
lyase activity
ligase activity
ligase
angiogenesis
cell proliferation
cellular response to starvation
response to glucose
regulation of endothelial cell migration
protein palmitoylation
ribosome biogenesis
regulation of sprouting angiogenesis
regulation of protein localization to nucleolus
neurotransmitter uptake
glutamate catabolic process
glutamine biosynthetic process
cellular amino acid biosynthetic process
ammonia assimilation cycle
positive regulation of insulin secretion
positive regulation of epithelial cell proliferation
protein homooligomerization
positive regulation of synaptic transmission, glutamatergic
glutamate metabolic process
nitrogen compound metabolic process
neurotransmitter metabolic process
