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Invitrogen
HCAR2/HCAR3 Polyclonal Antibody
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HCAR2/HCAR3 Antibody (PA5-99937) in ICC/IF
Immunocytochemistry analysis of HCAR2/HCAR3 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with HCAR2/HCAR3 polyclonal antibody (Product # PA5-99937) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugate... View More
产品信息
PA5-99937
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HCAR2(Accession Q8TDS4), corresponding to amino acid residues F304-S354.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total GPR109A/B.
靶标信息
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G protein-coupled receptor 109A; G protein-coupled receptor 109B; G protein-coupled receptor HM74a; G-protein coupled receptor 109A; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74A; G-protein coupled receptor HM74B; GTP-binding protein; hydroxy-carboxylic acid receptor 2; hydroxy-carboxylic acid receptor 3; Hydroxycarboxylic acid receptor 2; Hydroxycarboxylic acid receptor 3; Niacin receptor 1; Niacin receptor 2; Nicotinic acid receptor; Nicotinic acid receptor 2; putative chemokine receptor
基因别名: GPR109A; GPR109B; HCA2; HCA3; HCAR2; HCAR3; HM74; HM74A; HM74B; NIACR1; NIACR2; Puma-g; PUMAG
UniProt ID: (Human) Q8TDS4, (Human) P49019
Entrez Gene ID: (Human) 338442, (Human) 8843
