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Invitrogen
HLA-DR/DP Polyclonal Antibody
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产品信息
PA5-103071
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HLA-DRB1(Accession P01911), corresponding to amino acid residues L15-E65.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total HLA-DRB1.
靶标信息
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008].
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell surface glycoprotein; integral membrane protein; class II HLA histocompatibility antigen; DP beta 1 domain protein; DRB52; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA DP4 beta-chain; HLA-D; HLA-DP histocompatibility type, beta-1 subunit; HLA-DR; HLA-DR-beta chain; HLA-DRB1; human leucocyte antigen DRB1; Human leukocyte antigen DRB1; light chain; lymphocyte antigen DRB1; MHC Class 2; MHC class II; MHC class II antigen DPB1; MHC class II HLA-DP-beta-1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR4 protein; MHC DR beta protein precursor; MHC DR-beta; MHC DR7-beta-2 chain; MHC HLA DPB1; MHC HLA DR5 cell surface glycoprotein beta chain precursor; MHC HLA-D; MHC HLA-DPw4b-beta chain precursor; MHC HLA-DR-beta chain precursor; MHC HLA-DR-beta chain precursor old gene name 'HLA-DRA1'; MHC HLA-DR-beta-1 chain; MHC HLA-DR-beta-2 precursor; MHC HLA-DR1-beta; MHC HLA-DR2 (non-Dw2/non-Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw2)b glycoprotein beta-chain; MHC HLA-DRw10-beta-2 protein precursor; MHC HLA-SB-beta chain I; MHC II HLA; SB-beta chain; unnamed protein product
基因别名: DPB1; DRB1; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1; HLA-DR1B; HLA-DRB; HLA-DRB1; SS1
UniProt ID: (Human) P79608, (Human) P01911
Entrez Gene ID: (Human) 3115, (Human) 3123
adaptive immune response
immune system process
peptide antigen assembly with MHC class II protein complex
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
immune response
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of interferon-gamma production
positive regulation of T cell proliferation
positive regulation of immune response
T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of T cell mediated cytotoxicity
positive regulation of protein phosphorylation
inflammatory response to antigenic stimulus
myeloid dendritic cell antigen processing and presentation
antigen processing and presentation of endogenous peptide antigen via MHC class II
positive regulation of T cell mediated immune response to tumor cell
negative regulation of inflammatory response to antigenic stimulus
humoral immune response
cytoskeleton organization
signal transduction
epidermis development
detection of bacterium
macrophage differentiation
regulation of interleukin-10 production
regulation of interleukin-4 production
negative regulation of interferon-gamma production
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of kinase activity
positive regulation of insulin secretion involved in cellular response to glucose stimulus
T-helper 1 type immune response
negative regulation of T cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of memory T cell differentiation
positive regulation of MAPK cascade
regulation of T-helper cell differentiation
positive regulation of monocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of viral entry into host cell
protein tetramerization
positive regulation of ERK1 and ERK2 cascade
positive regulation of CD4-positive, alpha-beta T cell activation
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