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Huntingtin Polyclonal Antibody

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查看其他27个Huntingtin抗体

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Huntingtin Polyclonal Antibody

产品信息

PA5-85721

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

免疫细胞化学 (ICC/IF)

1:100-1:1,000
-

免疫沉淀 (IP)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Huntingtin. The exact sequence is proprietary.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.4 mg/mL

规格

140 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2792860

产品详细信息

Keep as concentrated solution.

Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Sheep (100%).

Positive Control: U87-MG.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HD protein; HD protein homolog; Huntingtin; huntingtin (Huntington disease); Huntington disease gene homolog; Huntington disease protein; huntington disease protein homolog; unnamed protein product

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基因别名: AI256365; C430023I11Rik; HD; Hdh; HTT; IT15; LOMARS

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UniProt ID: (Human) P42858

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Entrez Gene ID: (Human) 3064, (Rat) 29424, (Mouse) 15194

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功能
p53 binding phosphoprotein phosphatase activity protein binding profilin binding kinase binding heat shock protein binding dynactin binding identical protein binding ion channel binding dynein intermediate chain binding beta-tubulin binding receptor binding transcription factor binding diazepam binding
参与通路
urea cycle citrulline metabolic process establishment of mitotic spindle orientation protein import into nucleus mitochondrial transport ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER apoptotic process mitochondrion organization endoplasmic reticulum organization Golgi organization dopamine receptor signaling pathway spermatogenesis gastrulation central nervous system development brain development cell aging learning or memory learning grooming behavior locomotory behavior axo-dendritic transport associative learning determination of adult lifespan visual learning anatomical structure morphogenesis anterior/posterior pattern specification endosomal transport lactate biosynthetic process from pyruvate quinolinate biosynthetic process striatum development olfactory lobe development neural plate formation neurogenesis peptide hormone secretion insulin secretion positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity regulation of protein phosphatase type 2A activity social behavior hormone metabolic process negative regulation of apoptotic process negative regulation of neuron apoptotic process regulation of mitochondrial membrane permeability vesicle transport along microtubule regulation of synaptic plasticity paraxial mesoderm formation animal organ development neuron development mRNA transport neuron apoptotic process response to calcium ion regulation of mitochondrial membrane potential L-glutamate import iron ion homeostasis negative regulation of neuron death negative regulation of cysteine-type endopeptidase activity negative regulation of extrinsic apoptotic signaling pathway microtubule-based process regulation of signal transduction protein destabilization vocal learning positive regulation of apoptotic process positive regulation of cilium assembly synaptic vesicle transport positive regulation of mitophagy positive regulation of lipophagy regulation of CAMKK-AMPK signaling cascade positive regulation of CAMKK-AMPK signaling cascade positive regulation of aggrephagy embryo development
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