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Antibody detects endogenous levels of total Bone Sialoprotein.
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Bone sialoprotein 2; Bone sialoprotein II; BSP II; Cell-binding sialoprotein; integrin binding sialoprotein; Integrin-binding sialoprotein
基因别名: BNSP; BSP; BSP II; BSP-II; Bsp2; BSPII; IBSP; SP-II
UniProt ID: (Human) P21815, (Mouse) Q61711
Entrez Gene ID: (Human) 3381, (Mouse) 15891, (Rat) 24477
分子生物学功能: extracellular matrix protein extracellular matrix structural protein