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Invitrogen
ICSA Polyclonal Antibody
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ICSA Antibody (PA5-144412) in WB
Western blot analysis of ICSA in recombinant protein using a dilution of 1:2,000. Samples were incubated with ICSA polyclonal antibody (Product # PA5-144412). Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 40.3 kDa. Observed band size: 45 kDa.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-144412
产品规格
种属反应
Bacteria
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Shigella flexneri ICSA protein (311-547aa)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.745 mg/mL
规格
174.5 µg
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% Proclin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
An immunogenic protein essential for bacterial spreading, it elicits polar deposition of filamentous actin (actin-based motility) (PubMed:2542950, PubMed:8702989). Inside the host (human) cell mediates nucleation and polymerization of actin molecules on the bacterial surface, which provides the propulsive force for intracellular movement and intercellular dissemination of the bacterium (PubMed:2644195, PubMed:8468279, PubMed:2542950). During invasion of mammalian cells, triggers autophagy by binding to host ATG5. Interaction with IcsB leads to escape from the host autophagy defense system (PubMed:15576571). Binds ATP and displays weak ATPase activity (PubMed:8468279). Mediates polar adhesion to host cells and their invasion. The bile salt deoxycholate activates adhesion and invasion of host cells, possibly by altering IcsA's conformation. The adhesion and intercellular dissemination phenotypes can be separated (PubMed:24721572).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: virG
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