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IKK beta Polyclonal Antibody

查看其他41个IKK beta抗体

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IKK beta Polyclonal Antibody

产品信息

PA5-87491

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 400-669 of IKK beta (NP_0015471)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.76 mg/mL

规格

76 µg

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2804196

产品详细信息

Immunogen sequence: QISPRPQPES VSCILQEPKR NLAFFQLRKV WGQVWHSIQT LKEDCNRLQQ GQRAAMMNLL RNNSCLSKMK NSMASMSQQL KAKLDFFKTS IQIDLEKYSE QTEFGITSDK LLLAWREMEQ AVELCGRENE VKLLVERMMA LQTDIVDLQR SPMGRKQGGT LDDLEEQARE LYRRLREKPR DQRTEGDSQE MVRLLLQAIQ SFEKKVRVIY TQLSKTVVCK QKALELLPKV EEVVSLMNED EKTVVRLQEK RQKELWNLLK IACSKVRGPV

Positive Samples: Jurkat, HepG2; Cellular Location: Cytoplasm, Membrane raft, Nucleus

靶标信息

Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex. Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; nuclear factor kappa B kinase subunit beta; Nuclear factor NF-kappa-B inhibitor kinase beta; Serine/threonine protein kinase IKBKB; unnamed protein product

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基因别名: IKBKB; IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A; IMD15B; NFKBIKB

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UniProt ID: (Human) O14920

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Entrez Gene ID: (Human) 3551

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功能
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding IkappaB kinase activity kinase activity transferase activity protein kinase binding identical protein binding protein homodimerization activity protein heterodimerization activity scaffold protein binding protein serine kinase activity transferrin receptor binding
参与通路
protein polyubiquitination pattern recognition receptor signaling pathway stimulatory C-type lectin receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent MyD88-dependent toll-like receptor signaling pathway regulation of transcription from RNA polymerase II promoter protein phosphorylation inflammatory response I-kappaB kinase/NF-kappaB signaling response to virus positive regulation of macromolecule metabolic process regulation of tumor necrosis factor-mediated signaling pathway peptidyl-serine phosphorylation signal transduction involved in regulation of gene expression tumor necrosis factor-mediated signaling pathway regulation of toll-like receptor signaling pathway toll-like receptor 3 signaling pathway TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade protein maturation interleukin-1-mediated signaling pathway cellular response to tumor necrosis factor protein localization to plasma membrane negative regulation of cytokine production involved in inflammatory response regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly
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