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Bethyl Laboratories
ILK Polyclonal Antibody
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ILK Antibody (A301-258A) in ICC/IF
Detection of human ILK by immunocytochemistry. Sample: Acetone-fixed asynchronous HeLa cells. Antibody: Affinity purified rabbit anti-ILK (Product # A301-258A) (lot 1) used at a dilution of 1:100 (2 µg/mL). Detection: Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody used at a dilution of 1:100.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
A301-258A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 402 and 451 of human integrin-linked kinase.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.20 mg/mL
规格
20 µg
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For ICC, acetone fixation is recommended. Permeabilization is not recommended. Formaldehyde fixation is not recommended.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Guinea pig_10141 and Orangutan
靶标信息
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ILK-1; ILK-2; Inactive integrin-linked kinase; integrin binding protein kinase; Integrin linked ILK; integrin-linked protein kinase; p59ILK; Scaffold protein ILK
基因别名: AA511515; ESTM24; ILK; ILK1; ILK2
UniProt ID: (Mouse) O55222
Entrez Gene ID: (Mouse) 16202
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
signal transducer activity
integrin binding
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
SH3 domain binding
protein kinase binding
non-receptor serine/threonine protein kinase
regulation of cell growth
branching involved in ureteric bud morphogenesis
positive regulation of cell-matrix adhesion
protein phosphorylation
negative regulation of protein kinase activity
cell cycle arrest
integrin-mediated signaling pathway
cell aging
positive regulation of cell proliferation
regulation of signal transduction
negative regulation of cardiac muscle cell apoptotic process
fibroblast migration
Schwann cell development
negative regulation of smooth muscle cell migration
phosphorylation
peptidyl-serine phosphorylation
nerve development
myelination in peripheral nervous system
cell projection organization
positive regulation of cell migration
positive regulation of BMP signaling pathway
myelin assembly
regulation of actin cytoskeleton organization
substrate adhesion-dependent cell spreading
positive regulation of phosphorylation
negative regulation of apoptotic process
extracellular fibril organization
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
protein kinase B signaling
negative regulation of neuron apoptotic process
establishment or maintenance of epithelial cell apical/basal polarity
positive regulation of myoblast differentiation
positive regulation of osteoblast differentiation
positive regulation of axon extension
positive regulation of transcription, DNA-templated
negative regulation of smooth muscle cell proliferation
neuron projection morphogenesis
positive regulation of axonogenesis
positive regulation of dendrite morphogenesis
protein heterooligomerization
positive regulation of protein kinase B signaling
platelet aggregation
positive regulation of canonical Wnt signaling pathway
negative regulation of neural precursor cell proliferation
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