Search

  • Order Status
  • Quick Order
  • Promos

Rockland

IRF3 Polyclonal Antibody

查看其他53个IRF3抗体

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

产品信息

600-401-CA2

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-4 µg/mL
-

免疫组化（石蜡） (IHC (P))

Assay-dependent
-

免疫细胞化学 (ICC/IF)

2 µg/mL
-

酶联免疫吸附实验 (ELISA)

1:10,000-1:40,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Anti-IRF3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to 14 amino acids near the internal region of human IRF3.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling. It is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: Interferon regulatory factor 3; IRF-3; IRF-3a; IRF-3b; IRF-3c; IRF-3d; IRF-3e; IRF-3f; IRF3 (phospho S386); IRF3 (pS386); IRF3 (pSer386); IRF3 phospho; IRF3 phospho S386; IRF3 phospho Ser386; phospho IRF3; unnamed protein product

查看更多 收起

基因别名: IIAE7; IRF3

查看更多 收起

UniProt ID: (Human) Q14653

查看更多 收起

Entrez Gene ID: (Human) 3661

查看更多 收起

功能
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein domain specific binding identical protein binding protein homodimerization activity sequence-specific DNA binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding
参与通路
negative regulation of transcription from RNA polymerase II promoter positive regulation of cytokine production immune system process cytoplasmic pattern recognition receptor signaling pathway regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process cellular response to DNA damage stimulus cell surface receptor signaling pathway mRNA transcription response to bacterium regulation of gene expression programmed cell death signal transduction involved in regulation of gene expression lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to lipopolysaccharide positive regulation of interferon-alpha production positive regulation of interferon-beta production toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway MDA-5 signaling pathway regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA innate immune response positive regulation of innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of inflammatory response defense response to virus type I interferon signaling pathway positive regulation of type I interferon-mediated signaling pathway cellular response to lipopolysaccharide cellular response to exogenous dsRNA macrophage apoptotic process programmed necrotic cell death cellular response to virus antiviral innate immune response cGAS/STING signaling pathway positive regulation of cytokine production involved in inflammatory response
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持