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Invitrogen
Importin 11 Polyclonal Antibody
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Importin 11 Antibody (PA5-89980) in WB
Western blot analysis of Importin 11 in extracts of various cell lines. Samples were incubated with Importin 11 Polyclonal antibody (Product # PA5-89980) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
产品信息
PA5-89980
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment)
偶联物
形式
Liquid
浓度
2.74 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: KGIIEGERYP VVMSTYLGVM GRVLLQNTSF FSSLLNEMAH KFNQEMDQLL GNMIEMWVDR MDNITQPERR KLSALALLSL LPSDNSVIQD KFCGIINISV EGLHDVMTED PETGTYKDCM LMSHLEEPKV TEDEEPPTEQ DKRKKMLALK DPVHTVSLQQ FIYEKLKAQQ EMLGEQGFQS LMETVDTEIV TQLQEFLQGF; Positive Samples: HeLa, 293T, A-549, Mouse heart, Mouse kidney, Mouse lung, Mouse spleen, Mouse testis; Cellular Location: Cytoplasm, Nucleus
靶标信息
IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. It mediates the nuclear import of UBE2E3, and of RPL12.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Imp11; Importin-11; Ran binding protein 11; Ran-binding protein 11; RanBP11
基因别名: 1700081H05Rik; 2510001A17Rik; AI314624; AW555235; E330021B14Rik; IPO11; RANBP11
UniProt ID: (Human) Q9UI26, (Mouse) Q8K2V6
Entrez Gene ID: (Human) 51194, (Mouse) 76582
