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Invitrogen
KCNQ2 Polyclonal Antibody
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FIGURE: 1 / 10
KCNQ2 Antibody (PA1-929) in ICC/IF
Immunofluorescent analysis of KCNQ2 using Anti-KCNQ2 Polyclonal Antibody (Product # PA1-929) shows staining in HepG2 Cells. KCNQ2 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing KCNQ2 (Product # PA1-929) at a dilution of 1:100 over night at 4°C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product # 35552, Go... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-929
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Gerbil,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GST fusion protein encoding the first 70 amino acids of human KCNQ2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-929 detects KCNQ2 from mouse, human and rat samples. This antibody is specific for KCNQ2 and does not detect KCNQ1, KCNQ3, KCNQ4 or KCNQ5.
PA1-929 has been successfully used in Western blot, immunofluorescence, immunohistochemistry and immunocytochemistry procedures. Immunohistochemical staining of rat hippocampal using PA1-929 yielded a strong signal in granule cell layer and the mossy fibers found in the central hilus of the dentate gyrus.
PA1-929 immunogen is a GST fusion protein encoding the first 70 amino acids of human KCNQ2.
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system and KNCQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: KQT like 2; KQT-like 2; KVEBN1; neuroblastoma-specific potassium channel subunit alpha KvLQT2; potassium channel subunit alpha KvLQT2; potassium channel, voltage gated KQT-like subfamily Q, member 2; potassium channel, voltage-gated KQT-like subfamily Q, member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; unnamed protein product; voltage-gated potassium channel subunit Kv7.2
Gene Aliases: BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11; KQT2; KV7.2; Nmf134
UniProt ID: (Human) O43526, (Rat) O88943, (Mouse) Q9Z351
Entrez Gene ID: (Human) 3785, (Rat) 170848, (Mouse) 16536
action potential
protein phosphorylation
protein import into nucleus
ion transport
potassium ion transport
exocytosis
endocytosis
brain development
sensory perception of sound
learning
memory
grooming behavior
determination of adult lifespan
response to temperature stimulus
response to xenobiotic stimulus
response to mechanical stimulus
gene expression
response to auditory stimulus
protein transport
neuron remodeling
transmission of nerve impulse
neuronal action potential
dentate gyrus development
nerve development
hippocampus development
establishment of cell polarity
neuron differentiation
ion transmembrane transport
social behavior
exploration behavior
sodium ion transmembrane transport
psychomotor behavior
regulation of membrane potential
regulation of synaptic plasticity
cognition
neuron apoptotic process
mitochondrial depolarization
transmembrane transport
motor behavior
cellular response to calcium ion
cellular response to xenobiotic stimulus
potassium ion transmembrane transport
apoptosome assembly
hippocampal pyramidal neuron differentiation
excitatory chemical synaptic transmission
inhibitory chemical synaptic transmission
action potential initiation
regulation of action potential firing threshold
substantia propria of cornea development
chemical synaptic transmission
nervous system development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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