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Abnova
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Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MRMEAGEAAP PAGAGGRAAG GWGKWVRLNV GGTVFLTTRQ TLCREQKSFL SRLCQGEELQ SDRDETGAYL IDRDPTYFGP ILNFLRHGKL VLDKDMAEEG VLEEAEFYNI GPLIRIIKDR MEEKDYTVTQ VPPKHVYRVL QCQEEELTQM VSTMSDGWRF EQLVNIGSSY NYGSEDQAEF LCVVSKELHS TPNGLSSESS RKTKSTEEQL EEQQQQEEEV EEVEVEQVQV EADAQEKGSR PHPLRPEAEL AVRASPRPLA RPQSCHPCCY KPEAPGCEAP DHLQGLGVPI
Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BTB/POZ domain-containing protein KCTD17
基因别名: KCTD17
UniProt ID: (Human) Q8N5Z5
Entrez Gene ID: (Human) 79734