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Invitrogen
KCTD4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-59272
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LNFLRNGELL LPEGFRENQL LAQEAEFFQL KGLAEEVKSR WEKEQLTPRE TTFLEITDNH DRSQGLRIFC NAPDF
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 99%.
靶标信息
The KCTD4 (Potassium Channel Tetramerization Domain Containing 4) gene encodes a protein involved in various cellular processes, including the regulation of calcium homeostasis and modulation of fibroblast activity. KCTD4 interacts with chloride intracellular channel 1 (CLIC1) to disrupt calcium homeostasis, leading to increased fibronectin secretion, which activates fibroblasts via paracrine signaling. This activation can promote cancer cell invasion through matrix metalloproteinase 24 (MMP24) signaling. The interaction between KCTD4 and CLIC1 presents a potential target for therapeutic strategies, as inhibition of this interaction has been shown to significantly suppress cancer metastasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
