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Invitrogen
Ku80 Monoclonal Antibody (5C5)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-15873
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
5C5
抗原
Purified recombinant fragment of human XRCC5 expressed in E. Coli.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-15873 targets XRCC5 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human and mouse samples.
The MA5-15873 immunogen is purified recombinant fragment of human XRCC5 expressed in E. Coli. .
MA5-15873 detects XRCC5 which has a predicted molecular weight of approximately 86kDa.
靶标信息
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein Ku80; DNA repair protein XRCC5; FLJ39089; HGNC:12833; Ku autoantigen protein p86 homolog; Ku p80; Ku-80; Ku-86; Ku80; Lupu; lupus; Nuclear factor IV; OTTHUMP00000164061; OTTHUMP00000206791; X-ray repair cross-complementing protein 5
基因别名: AI314015; G22p2; Ku80; Ku86; Xrcc5
UniProt ID: (Mouse) P27641
Entrez Gene ID: (Mouse) 22596
nucleotide binding
DNA binding
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
ATP-dependent DNA helicase activity
helicase activity
ATP binding
protein C-terminus binding
hydrolase activity
hydrolase activity, acting on acid anhydrides
ubiquitin protein ligase binding
telomeric DNA binding
transcription regulatory region DNA binding
poly(A) RNA binding
5'-deoxyribose-5-phosphate lyase activity
DNA helicase
telomere maintenance
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
cell proliferation
negative regulation of transcription, DNA-templated
positive regulation of neurogenesis
hematopoietic stem cell differentiation
cellular hyperosmotic salinity response
cellular response to X-ray
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