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Invitrogen
LEFTY Polyclonal Antibody
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LEFTY Antibody (PA5-90431) in WB
Western blot analysis of LEFTY in extracts of various cell lines. Samples were incubated with LEFTY Polyclonal antibody (Product # PA5-90431) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
产品信息
PA5-90431
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 77-366 of human LEFTY1 (NP_0662771)
偶联物
形式
Liquid
浓度
1.27 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: RFSQSFREVA GRFLALEAST HLLVFGMEQR LPPNSELVQA VLRLFQEPVP KAALHRHGRL SPRSARARVT VEWLRVRDDG SNRTSLIDSR LVSVHESGWK AFDVTEAVNF WQQLSRPRQP LLLQVSVQRE HLGPLASGAH KLVRFASQGA PAGLGEPQLE LHTLDLGDYG AQGDCDPEAP MTEGTRCCRQ EMYIDLQGMK WAENWVLEPP GFLAYECVGT CRQPPEALAF KWPFLGPRQC IASETDSLPM IVSIKEGGRT RPQVVSLPNM RVQKCSCASD GALVPRRLQP; Positive Samples: HT-29, SW480, BxPC-3, Mouse pancreas, Mouse spleen, Rat pancreas
靶标信息
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Left-right determination factor 1; Left-right determination factor B; left-right determination, factor B; Lefty protein; Protein lefty-1; Protein lefty-B; Stimulated by retinoic acid gene 3 protein; TGF-beta-4; Transforming growth factor beta-4
基因别名: AI450052; Ebaf; LEFTB; Lefty; lefty-1; LEFTY1; LEFTYB; Stra3; Tgfb4; UNQ278/PRO317
UniProt ID: (Human) O75610, (Mouse) Q64280
Entrez Gene ID: (Human) 10637, (Mouse) 13590
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
transforming growth factor beta receptor signaling pathway
determination of left/right symmetry
positive regulation of pathway-restricted SMAD protein phosphorylation
cell growth
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
multicellular organism development
negative regulation of cell proliferation
anterior/posterior axis specification
response to retinoic acid
growth
cell migration involved in gastrulation
negative regulation of nodal signaling pathway
negative regulation of nodal receptor complex assembly
