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Bethyl Laboratories
LONP1/PRSS15 Polyclonal Antibody
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FIGURE: 1 / 1
LONP1/PRSS15 Antibody (A304-800A) in WB
Detection of human LONP1/PRSS15 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, and Jurkat cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-LONP1/PRSS15 antibody (Product # A304-800A) (lot A304-800A-1) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A304-800A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 909 to 959 of human Lon protease homolog, mitochondrial.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: h LonHS; hLON ATP-dependent protease; Lon protease homolog, mitochondrial; Lon protease-like protein; LONHs; LONP; Mitochondrial ATP-dependent protease Lon; mitochondrial lon protease-like protein; Serine protease 15; unnamed protein product
Gene Aliases: CODASS; hLON; LON; LonHS; LONP; LONP1; PIM1; PRSS15
UniProt ID: (Human) P36776
Entrez Gene ID: (Human) 9361
nucleotide binding
mitochondrial RNA polymerase regulatory region DNA binding
DNA binding
single-stranded DNA binding
single-stranded RNA binding
ATP-dependent peptidase activity
serine-type endopeptidase activity
protein binding
ATP binding
peptidase activity
serine-type peptidase activity
hydrolase activity
ATPase activity
PH domain binding
identical protein binding
ADP binding
insulin receptor substrate binding
sequence-specific DNA binding
G-quadruplex DNA binding
DNA polymerase binding
mitochondrial genome maintenance
response to hypoxia
proteolysis
misfolded or incompletely synthesized protein catabolic process
mitochondrion organization
response to hormone
response to aluminum ion
protein catabolic process
mitochondrial DNA metabolic process
cellular response to oxidative stress
mitochondrial protein catabolic process
negative regulation of insulin receptor signaling pathway
chaperone-mediated protein complex assembly
proteolysis involved in cellular protein catabolic process
protein-containing complex assembly
oxidation-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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