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Invitrogen
LRRC23 Polyclonal Antibody
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产品信息
PA5-63449
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
C. elegans
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LKADGNRLRS AQMNELPYLQ IASFAYNQIT DTEGISHPRL ETLNLKGNSI HMVTGLDPEK LISLHTVELR GNQLESTLGI NLPKLKNLYL A
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 81%.
靶标信息
The LRRC23 (Leucine-Rich Repeat Containing 23) gene encodes a protein that is an evolutionarily conserved component of the radial spoke complex in sperm flagella. It is located on human chromosome 12. The LRRC23 protein interacts with radial spoke head proteins such as RSPH3A and RSPH3B, crucial for the structural integrity and proper function of the radial spokes, which are essential for flagellar motility. Mutations or deficiencies in LRRC23 have been linked to male infertility, specifically causing asthenozoospermia, characterized by reduced sperm motility. Studies have identified various mutations in LRRC23 that result in disorganized radial spokes and impaired sperm motility, leading to infertility
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Leucine-rich protein B7; Leucine-rich repeat-containing protein 23
基因别名: LRPB7; LRRC23
UniProt ID: (Human) Q53EV4
Entrez Gene ID: (Human) 10233
