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Invitrogen
LRRC4 Polyclonal Antibody
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LRRC4 Antibody (PA5-78649) in WB
Western Blot using LRRC4 Polyclonal Antibody (Product # PA5-78649). Various tissue extracts (75 µg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with LRRC4 Polyclonal Antibody (Product # PA5-78649) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
PA5-78649
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the Intracellular domain of mouse LRRC4. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: m brain, brain
Predicted Reactivity: Human (98%), Rhesus Monkey (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The LRRC4 gene, also known as netrin-G ligand 2 (NGL-2), is a brain-specific member of the leucine-rich repeat superfamily, playing a critical role in the central nervous system. Its expression is particularly high in areas such as the hippocampal CA1 and CA2 regions, as well as in granule cells of the dentate gyrus. LRRC4 is a known tumor suppressor gene associated with glioma suppression, as it regulates glioma cell growth, angiogenesis, and invasion through extensive signaling networks. It can participate in multiphase loops involving miRNA, transcription factors, and gene methylation modifications. This gene targets various genes involved in cell motility, impacting glioblastoma cell movement and polarization by binding to enhancer elements and activating transcription, notably the RAP1GAP gene. Its function and expression are crucial in maintaining normal brain function and hold potential implications in the management of gliomagenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brain tumor-associated protein MBAG1; leucine rich repeat containing 4 protein; Leucine-rich repeat-containing protein 4; LIBG-like protein; LRRC4-like protein; Netrin-G2 ligand; NGL-2; NLG2; protein NGL-2
基因别名: Lrrc4; MBAG1; Nag14; NGL-2; NLG-2
UniProt ID: (Mouse) Q99PH1, (Rat) Q45R42
Entrez Gene ID: (Mouse) 192198, (Rat) 641521
