Invitrogen

Laminin Polyclonal Antibody

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36 篇参考文献
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Laminin Polyclonal Antibody

产品信息

PA1-16730

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:5,000
查看2篇已发表文章 2篇已发表文章

免疫组化 (IHC)

-
查看23篇已发表文章 23篇已发表文章

免疫组化（石蜡） (IHC (P))

1:500-1:2,000
查看2篇已发表文章 2篇已发表文章

免疫组化（冰冻） (IHC (F))

1:500-1:2,000
-

免疫组织化学（悬浮细胞） (IHC (Free))

1:1,000-1:5,000
-

免疫细胞化学 (ICC/IF)

1:1,000-1:5,000
查看6篇已发表文章 6篇已发表文章

流式细胞分析 (Flow)

Assay-Dependent
查看2篇已发表文章 2篇已发表文章

亲和纯化 (AP)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Hamster, Human, Invertebrate, Mammal, Mouse, Sheep, Rabbit, Rat

已发表种属

C. elegans, Dog, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Laminin 111 isolated from mouse Engelbreth-Holm-Swarm (EHS) sarcoma cells.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 50% glycerol

内含物

0.035% sodium azide

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2133633

产品详细信息

This antibody is pan-specific and reacts well with all Laminin isoforms tested: Laminin-1 (alpha-1, beta-1, and gamma-1) and Laminin-2 (alpha-2, beta-1, and gamma-1).

The antibody functionally inhibits Laminin in mouse and rat. It binds to Laminin and inhibits most, if not all, of its cell adhesion and growth promotive properties. Immunostaining is enhanced by antigen retrieval with pepsin, especially paraffin tissue. Suggested positive control: basement membranes (blood vessels of any tissue, tumors, nerve).

靶标信息

Laminin is a crucial glycoprotein that plays a significant role in the extracellular matrix, particularly within the basement membrane. It is composed of three subunits: alpha, beta, and gamma chains. These chains are disulfide-linked polypeptides that together form a heterotrimer, resembling the shape of a cross. The human genome encodes 11 genetically distinct laminin chains, which combine to form over 14 different laminin isoforms, each with specific tissue distributions and functions. Laminins can bind to other laminin molecules, as well as integrins and other matrix proteins, providing structural support and influencing cell differentiation, migration, and adhesion. These glycoproteins are vital during early embryonic development, where they contribute to the formation of basement membrane-like structures, even in the absence of type IV collagen. The evolutionary origin of laminin gene families can be traced back to early branching animals, providing insights into metazoan gene family development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: dystrophia muscularis; Laminin A chain; laminin alpha 2 subunit; laminin B1; Laminin B1 chain; laminin B1 subunit 1; Laminin B2 chain; Laminin M chain; Laminin subunit alpha-1; Laminin subunit alpha-2; Laminin subunit beta-1; Laminin subunit gamma-1; laminin, alpha 1; laminin, alpha 2; laminin, beta 1; laminin, gamma 1 (formerly LAMB2); laminin-1; Laminin-1 subunit alpha; Laminin-1 subunit beta; Laminin-1 subunit gamma; Laminin-10 subunit beta; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-12 subunit alpha; Laminin-12 subunit beta; Laminin-2 subunit alpha; Laminin-2 subunit beta; Laminin-2 subunit gamma; Laminin-3 subunit alpha; Laminin-3 subunit gamma; Laminin-4 subunit alpha; Laminin-4 subunit gamma; Laminin-6 subunit beta; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit beta; Laminin-8 subunit gamma; Laminin-9 subunit gamma; Merosin heavy chain; S-LAM alpha; S-LAM gamma; S-laminin subunit alpha; S-laminin subunit gamma

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基因别名: 5830440B04; AA408497; B2e; C77966; C80098; C81607; CLM; D130003D08Rik; dy; I79_015129; I79_017505; LAMA; Lama-1; LAMA1; LAMA2; Lamb-1; LAMB1; Lamb1-1; LAMB2; LAMC1; LAMM; LIS5; mer; merosin; mKIAA4087; PTBHS; S-LAM-alpha

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UniProt ID: (Human) P25391, (Human) P24043, (Human) P07942, (Human) P11047, (Mouse) P19137, (Mouse) Q60675, (Mouse) P02469

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Entrez Gene ID: (Human) 284217, (Sheep) 101102692, (Rabbit) 100357482, (Rabbit) 100350500, (Human) 3908, (Sheep) 101117424, (Human) 3912, (Sheep) 101105743, (Rabbit) 100358679, (Human) 3915, (Rabbit) 103346447, (Sheep) 101105588, (Chinese hamster) 100765555, (Mouse) 16772, (Rat) 316758, (Rat) 309368, (Mouse) 16773, (Mouse) 16777, (Rat) 298941, (Chinese hamster) 100757343, (Rat) 117036, (Chinese hamster) 100761564, (Mouse) 226519

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