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Invitrogen
FAS Monoclonal Antibody (UT-1)
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FAS Antibody (MA1-19024) in WB
Western blot analysis was performed on membrane enriched cell extracts (30 µg lysate) of Jurkat (Lane 1), Raji (Lane 2), MOLT-4 (Lane 3), HeLa (Lane 4), MCF7 (Lane 5) and SW-480 (Lane 6). The blot was probed with anti-FAS Monoclonal Antibody (Product # MA1-19024, 1 µg/mL) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25 µg/mL, 1:4000 dilution). A 31 kDa band corresponding to FAS receptor was observed across all the cell lines tested. HeLa, MCF7 and SW-4... View More
产品信息
MA1-19024
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Mouse
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
UT-1
抗原
T cell lymphoma cells HUT-78.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C, do not freeze
运输条件
Wet ice
RRID
靶标信息
CD95, also known as Fas or APO-1, is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor in the tumor necrosis factor receptor (TNFR) superfamily. It is expressed by a wide range of hematopoietic and non-hematopoietic cells, including monocytes, neutrophils, lymphocytes, and fibroblasts. CD95 also exists in a soluble form weighing approximately 26 kDa. The interaction of CD95 with its ligand, FasL, induces apoptosis, playing a crucial role in peripheral tolerance and anti-viral immune responses. Upon stimulation, CD95 leads to the aggregation of its intracellular Fas-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases. This cascade results in apoptosis. CD95 is also involved in activating NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and transduces proliferative signals in normal diploid fibroblasts and T cells. There are at least eight alternatively spliced transcript variants encoding seven distinct isoforms of CD95. Isoforms lacking the transmembrane domain may negatively regulate apoptosis mediated by the full-length isoform. The Fas/Fas ligand system is implicated in several human diseases, including AIDS, hepatitis, and cancer, highlighting its importance in immune regulation and disease pathology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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