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Invitrogen
RANK Monoclonal Antibody (9A725), PE
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FIGURE: 1 / 3
RANK Antibody (MA1-41015) in Flow
Flow cytometry analysis of RANK in K-562 cells. Samples were incubated with RANK monoclonal antibody (Product # MA1-41015) using a dilution of 1 µg/mL for 30 minutes at room temperature. An intracellular stain was performed with primary antibody (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-41015
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Avian,
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
9A725
Immunogen
A fusion protein containing amino acid residues 326-616 of human RANK. Recognizes an epitope located between amino acid residues 330-427 of human RANK.
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.47 mg/mL
Amount
47 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes an epitope located between amino acid residues 330-427 of human RaNK.
Suggested positive control: Raw.
Target Information
RANK is a member of the tumor necrosis factor receptor (TNFR) family. The full length mouse RANK cDNA encodes a type I transmembrane protein with an extracellular and a cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNFR family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: familial expansile osteolysis; loss of heterozygosity, 18, chromosomal region 1; osteoclast differentiation factor receptor; Paget disease of bone 2; receptor activator of NF-kappaB; receptor activator of NF-KB; receptor activator of nuclear factor kappa B; receptor activator of nuclear factor-kappa B; TRANCE receptor; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene Aliases: CD265; FEO; LOH18CR1; Ly109; mRANK; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; RGD1563614; TRANCE-R; TRANCER
UniProt ID: (Human) Q9Y6Q6, (Mouse) O35305
Entrez Gene ID: (Human) 8792, (Rat) 498206, (Mouse) 21934
ossification
adaptive immune response
immune system process
monocyte chemotaxis
signal transduction
cell-cell signaling
positive regulation of cell proliferation
response to mechanical stimulus
osteoclast differentiation
response to lipopolysaccharide
response to insulin
tumor necrosis factor-mediated signaling pathway
cellular response to zinc ion starvation
response to tumor necrosis factor
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to ethanol
positive regulation of osteoclast differentiation
positive regulation of bone resorption
positive regulation of JNK cascade
lymph node development
circadian temperature homeostasis
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
positive regulation of fever generation by positive regulation of prostaglandin secretion
multinuclear osteoclast differentiation
positive regulation of NIK/NF-kappaB signaling
mammary gland alveolus development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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