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Invitrogen
TIMP2 Monoclonal Antibody (3A4), Biotin
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Product Details
MA5-12204
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Guinea pig,
Human,
Mouse,
Rabbit,
Rat
Published species
Bovine,
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3A4
Immunogen
A synthetic peptide from the N-terminal region of human TIMP-2 protein
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-12204 targets TIMP-2 in IHC (P) and WB applications and shows reactivity with Bovine, Guinea Pig, Human, mouse, Rabbit, and Rat samples.
The MA5-12204 immunogen is a synthetic peptide from the N-terminal region of human TIMP-2 protein.
Target Information
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Collagenase inhibitor; CSC-21K; Metalloproteinase inhibitor 2; metalloproteinase inhibitor precursor; metalloproteinase inhibitor TIMP-2; metalloproteinase-2 inhibitor precursor; testicular secretory protein Li 57; TIMP 2; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinase-2; Tissue inhibitor of metalloproteinases 2; tissue inhibitor of mettaloproteinase 2; unnamed protein product
Gene Aliases: CSC-21K; D11Bwg1104e; DDC8; Timp-2; TIMP2
UniProt ID: (Human) P16035, (Bovine) P16368, (Rat) P30121, (Guinea pig) Q9WUC6
Entrez Gene ID: (Human) 7077, (Rabbit) 100008689, (Bovine) 282093, (Rat) 29543, (Guinea pig) 100135629, (Mouse) 21858
response to hormone
response to cytokine
negative regulation of membrane protein ectodomain proteolysis
negative regulation of metallopeptidase activity
spermatogenesis
central nervous system development
aging
negative regulation of cell proliferation
negative regulation of endopeptidase activity
regulation of cAMP metabolic process
regulation of Rap protein signal transduction
response to drug
positive regulation of catalytic activity
negative regulation of catalytic activity
regulation of MAPK cascade
positive regulation of MAPK cascade
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of adenylate cyclase activity
negative regulation of proteolysis
negative regulation of mitotic cell cycle
negative regulation of Ras protein signal transduction
cellular response to organic substance
negative regulation of peptidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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