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CD61 (Integrin beta 3) Monoclonal Antibody (HM beta 3.1), FITC

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CD61 (Integrin beta 3) Monoclonal Antibody (HM beta 3.1), FITC

Product Details

MA5-28176

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Neat-1:10
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Hamster / IgG

Class

Monoclonal

Type

Antibody

Clone

HM beta 3.1

Immunogen

Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

100 µg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS with 1% BSA

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745152

Product Specific Information

This antibody recognizes the murine integrin beta 3 subunit (CD61), approximately a 90 kDa a type I membrane protein, expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively.

Target Information

CD61, also known as GPIIIa or ITGB3, is a 105 kDa glycoprotein expressed on activated T cells, granulocytes, megakaryocytes, platelets, and their precursors. It plays a crucial role in platelet aggregation and functions as a receptor for fibrinogen, fibronectin, von Willebrand factor, vitronectin, and thrombospondin. CD61 forms heterodimeric complexes by associating non-covalently with integrin alpha subunits: alphaV (CD51) to create the Vitronectin Receptor and alphaIIb (CD41) to form gpIIb/IIIa. These complexes are responsible for adhesion to extracellular matrix components, facilitating cell adhesion and cell-surface mediated signaling. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, and osteoclasts in association with CD51. The protein product of CD61 is composed of an alpha chain and a beta chain, which can combine with multiple partners to form different integrins. Its involvement in cell adhesion and signaling underscores its importance in normal physiological processes. Dysfunction of CD61 is associated with diseases such as Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder, highlighting its critical role in hemostasis and platelet function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GPIIIa; platelet glycoprotein IIIa (GP3A); platelet gpIIIa; platelet membrane glycoprotein IIIa; unnamed protein product

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Gene Aliases: CD61; GP3A; INGRB3

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UniProt ID: (Mouse) O54890

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Entrez Gene ID: (Mouse) 16416

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Function(s)
fibronectin binding protease binding protein disulfide isomerase activity obsolete cell adhesion receptor activity protein kinase C binding integrin binding protein binding fibroblast growth factor binding enzyme binding C-X3-C chemokine binding insulin-like growth factor I binding neuregulin binding identical protein binding vascular endothelial growth factor receptor 2 binding cell adhesion molecule binding extracellular matrix binding fibrinogen binding
Process(es)
positive regulation of endothelial cell proliferation positive regulation of cell-matrix adhesion positive regulation of leukocyte migration cell-substrate junction assembly cell adhesion cell-matrix adhesion integrin-mediated signaling pathway embryo implantation regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of fibroblast migration negative regulation of lipid storage negative regulation of low-density lipoprotein particle clearance response to activity smooth muscle cell migration positive regulation of smooth muscle cell migration cell migration platelet activation regulation of cell migration positive regulation of cell migration cell-substrate adhesion negative regulation of lipid transport regulation of protein localization regulation of actin cytoskeleton organization cell adhesion mediated by integrin positive regulation of cell adhesion mediated by integrin cell-cell adhesion mediated by integrin positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading response to platelet-derived growth factor cellular response to platelet-derived growth factor stimulus apolipoprotein A-I-mediated signaling pathway apoptotic cell clearance positive regulation of osteoclast differentiation positive regulation of angiogenesis positive regulation of bone resorption positive regulation of cell adhesion viral entry into host cell platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation mesodermal cell differentiation positive regulation of smooth muscle cell proliferation cell projection morphogenesis negative regulation of lipoprotein metabolic process regulation of developmental process negative chemotaxis regulation of multicellular organismal process regulation of release of sequestered calcium ion into cytosol regulation of neurotransmitter uptake regulation of serotonin uptake regulation of protein tyrosine kinase activity positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to mechanical stimulus cellular response to xenobiotic stimulus positive regulation of glomerular mesangial cell proliferation blood coagulation, fibrin clot formation maintenance of postsynaptic specialization structure regulation of postsynaptic neurotransmitter receptor internalization regulation of postsynaptic neurotransmitter receptor diffusion trapping positive regulation of substrate adhesion-dependent cell spreading positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway positive regulation of vascular endothelial growth factor signaling pathway regulation of extracellular matrix organization cellular response to insulin-like growth factor stimulus negative regulation of endothelial cell apoptotic process positive regulation of T cell migration
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