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Invitrogen
CD200R3 Monoclonal Antibody (Ba91)
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Product Details
MA5-33338
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
Ba91
Immunogen
Mouse primary basophils
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Product is supplied at 1 mL (100 µL/mL). Application notes: Flow Cytometry - MC/9 cells were washed, resuspended in FACS buffer (PBS with 2% BSA), and incubated for 30min with CD200R3 Monoclonal Antibody (Ba91).
Positive control: MC/9. Negative control: CFTL-15 cells, T-cells, B-cells, macrophages, neutrophils
Target Information
CD200R3 is a dimeric cell surface receptor also known as CD200RLb. CD200R3 contains two Ig-like extracellular domains and as such is a member of the immunoglobulin superfamily of receptors. The intracellular region of CD200R3 associates with the adaptor molecule DAP12, and possibly also DAP10, CD3 zeta and FcR gamma-chain, indicating that it is capable of transducing stimulatory signals. In this respect CD200R3 bears similarity to activatory receptors CD200R2 and CD200R4. In contrast, an inhibitory receptor CD200R (also known as CD200R1) relies on other adaptors. CD200R3 is primarily expressed by basophils and mast cells, cells known to be involved in anti-parasitic immune responses and frequently also allergic reactions. The surface expression of CD200R3 decreases when basophils are activated by ligating their CD16 and CD32. Remarkably, most of this downregulation is observed within the first 30 minutes after activation. Unlike CD200R, CD200R3 does not bind CD200.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD200 cell surface glycoprotein receptor 3; CD200 cell surface glycoprotein receptor-like 3; CD200 cell surface glycoprotein receptor-like b; CD200 receptor-like 3; CD200RLb; Cell surface glycoprotein CD200 receptor 3; Cell surface glycoprotein OX2 receptor 3
Gene Aliases: 4733401I18Rik; 4833409J19Rik; AI505817; BB106877; Cd200r3; Cd200rlb; mCD200RLb
UniProt ID: (Mouse) Q5UKY4
Entrez Gene ID: (Mouse) 74603
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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