TNF alpha Monoclonal Antibody (MAb11), PE

protease binding identical protein binding transcription regulatory region sequence-specific DNA binding cytokine activity tumor necrosis factor receptor binding protein binding death receptor agonist activity receptor agonist activity

negative regulation of transcription from RNA polymerase II promoter activation of MAPKKK activity activation of MAPK activity microglial cell activation negative regulation of endothelial cell proliferation chronic inflammatory response to antigenic stimulus positive regulation of chronic inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin glucose metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process humoral immune response JNK cascade intrinsic apoptotic signaling pathway in response to DNA damage response to virus vascular endothelial growth factor production negative regulation of alkaline phosphatase activity extracellular matrix organization osteoclast differentiation sequestering of triglyceride cortical actin cytoskeleton organization positive regulation of fever generation lipopolysaccharide-mediated signaling pathway negative regulation of interleukin-6 production positive regulation of interferon-gamma production positive regulation of interleukin-6 production positive regulation of interleukin-8 production receptor biosynthetic process positive regulation of peptidyl-serine phosphorylation positive regulation of heterotypic cell-cell adhesion negative regulation of myosin-light-chain-phosphatase activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of protein complex disassembly positive regulation of protein complex disassembly protein kinase B signaling positive regulation of JUN kinase activity positive regulation of neuron apoptotic process negative regulation of viral genome replication positive regulation of chemokine biosynthetic process positive regulation of nitric oxide biosynthetic process regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of osteoblast differentiation positive regulation of osteoclast differentiation negative regulation of mitotic cell cycle positive regulation of translational initiation by iron negative regulation of glucose import embryonic digestive tract development positive regulation of cytokine secretion positive regulation of phagocytosis regulation of insulin secretion positive regulation of synaptic transmission regulation of synapse organization defense response to Gram-positive bacterium leukocyte tethering or rolling negative regulation of lipid catabolic process regulation of immunoglobulin secretion positive regulation of membrane protein ectodomain proteolysis positive regulation of NF-kappaB transcription factor activity response to glucocorticoid positive regulation of hair follicle development positive regulation of protein kinase B signaling positive regulation of glial cell proliferation positive regulation of calcidiol 1-monooxygenase activity epithelial cell proliferation involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis negative regulation of branching involved in lung morphogenesis positive regulation of calcineurin-NFAT signaling cascade cellular response to amino acid stimulus cellular response to nicotine cellular response to organic cyclic compound positive regulation of podosome assembly endothelial cell apoptotic process protein localization to plasma membrane necroptotic signaling pathway positive regulation of cytokine production involved in inflammatory response negative regulation of beta-amyloid clearance positive regulation of NIK/NF-kappaB signaling positive regulation of synoviocyte proliferation positive regulation of superoxide dismutase activity positive regulation of beta-amyloid formation positive regulation of protein localization to plasma membrane regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly positive regulation of I-kappaB phosphorylation negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of vascular smooth muscle cell proliferation positive regulation of leukocyte adhesion to arterial endothelial cell positive regulation of protein localization to cell surface positive regulation of blood microparticle formation positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of endothelial cell apoptotic process positive regulation of estradiol secretion negative regulation of extrinsic apoptotic signaling pathway in absence of ligand response to hypoxia positive regulation of cytokine production positive regulation of protein phosphorylation negative regulation of L-glutamate transport macrophage activation involved in immune response regulation of immunoglobulin production positive regulation of immunoglobulin production negative regulation of cytokine production involved in immune response skeletal muscle contraction negative regulation of systemic arterial blood pressure defense response inflammatory response immune response JAK-STAT cascade circadian rhythm negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors response to xenobiotic stimulus response to mechanical stimulus response to bacterium response to salt stress response to fructose organ morphogenesis negative regulation of heart rate positive regulation of gene expression negative regulation of gene expression positive regulation of macrophage derived foam cell differentiation negative regulation of lipid storage response to activity regulation of metabolic process calcium-mediated signaling positive regulation of protein complex assembly positive regulation of defense response negative regulation of myelination response to nutrient levels response to lipopolysaccharide positive regulation of chemokine production positive regulation of fractalkine production positive regulation of interleukin-1 beta production positive regulation of interleukin-18 production tumor necrosis factor-mediated signaling pathway toll-like receptor 3 signaling pathway positive regulation of cellular amide metabolic process response to isolation stress response to macrophage colony-stimulating factor NIK/NF-kappaB signaling regulation of cell proliferation vasodilation defense response to bacterium positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAP kinase activity positive regulation of MAPK cascade negative regulation of blood vessel endothelial cell migration innate immune response cellular extravasation response to ethanol negative regulation of fat cell differentiation regulation of osteoclast differentiation positive regulation of protein catabolic process positive regulation of action potential positive regulation of cell adhesion positive regulation of lipid metabolic process positive regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade astrocyte activation positive regulation of smooth muscle cell proliferation regulation of protein secretion regulation of inflammatory response positive regulation of inflammatory response negative regulation of neurogenesis regulation of developmental process modulation of synaptic transmission cognition leukocyte migration detection of mechanical stimulus involved in sensory perception of pain regulation of secretion positive regulation of protein transport regulation of multicellular organismal process regulation of synaptic transmission, glutamatergic positive regulation of vitamin D biosynthetic process negative regulation of vascular wound healing regulation of biological quality positive regulation of ERK1 and ERK2 cascade cellular response to molecule of bacterial origin cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to interferon-gamma cellular response to ionizing radiation positive regulation of mononuclear cell migration negative regulation of oxidative phosphorylation inflammatory response to wounding apoptotic signaling pathway extrinsic apoptotic signaling pathway cellular response to toxic substance liver regeneration negative regulation of bile acid secretion antiviral innate immune response response to Gram-negative bacterium positive regulation of neuroinflammatory response positive regulation of interleukin-33 production response to L-glutamate positive regulation of neutrophil activation negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of cellular protein localization cellular response to beta-amyloid positive regulation of leukocyte adhesion to vascular endothelial cell regulation of membrane lipid metabolic process response to 3,3',5-triiodo-L-thyronine response to gold nanoparticle positive regulation of hepatocyte proliferation regulation of endothelial cell apoptotic process regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process negative regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway