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Invitrogen
CD55 Monoclonal Antibody (MEM-118), PE-Cyanine5
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FIGURE: 1 / 2
CD55 Antibody (MA562330) in Flow
Flow cytometry (surface staining) of CD55 in human peripheral whole blood. Samples were stained with CD55 monoclonal antibody (Product # MA562330) using a dilution of 4 µL reagent/100 µL of peripheral whole blood. Separation of human neutrophil granulocytes (red-filled) from CD55 negative lymphocytes (black-dashed).
Product Details
MA562330
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
MEM-118
Immunogen
HPB-ALL human T cell line.
Conjugate
Excitation/Emission Max
568/666 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
TBS, pH 8, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can regulate complement when bound to CD97. In tumors, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis. CD55 is a 70 kDa glycoprotein (in erythrocytes) anchored in the membrane by glycosylphosphatidylinositol tail. In other cells, the apparent molecular weight is somewhat larger for CD55 and has a substantial content of O-glycans. CD55 binds to activated C4b or C3b complement fragments on the cell surface, preventing the assembly and accelerating the decay of both classical and alternative pathways. CD55 carries the Cromer related blood group antigens. Two alternatively spliced transcripts encoding CD55 have been identified, and the predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. CD55 has been studied to have a role in prostate cancer growth and survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD55; CD55 antigen; CD55 molecule, decay accelerating factor for complement (Cromer blood group); Complement decay-accelerating factor; RP11-357P18.1
Gene Aliases: CD55; CR; CROM; DAF; TC
UniProt ID: (Human) P08174
Entrez Gene ID: (Human) 1604
ER to Golgi vesicle-mediated transport
complement activation, classical pathway
positive regulation of cytosolic calcium ion concentration
regulation of complement activation
regulation of lipopolysaccharide-mediated signaling pathway
CD4-positive, alpha-beta T cell cytokine production
innate immune response
respiratory burst
negative regulation of complement activation
viral entry into host cell
positive regulation of CD4-positive, alpha-beta T cell activation
positive regulation of CD4-positive, alpha-beta T cell proliferation
Performance Guarantee
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