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Invitrogen
MECOM Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115607
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MECOM(Accession Q03112), corresponding to amino acid residues I100-Y150.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total Myelodysplasia Syndrome 1.
靶标信息
The MECOM gene (MDS1 and EVI1 Complex Locus) is located on chromosome 3q26.2 and encodes a protein involved in transcriptional regulation. This gene produces multiple transcript variants encoding different isoforms, including MDS1, EVI1, and PRDM3. The EVI1 protein, one of the main isoforms, is characterized by zinc finger motifs, which facilitate DNA binding, and a SET domain responsible for methyltransferase activity. MECOM plays a crucial role in cell proliferation, differentiation, apoptosis, and hematopoiesis. Aberrations in MECOM, particularly overexpression or rearrangements, are associated with various hematological malignancies, including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The MECOM gene's normal function and pathological alterations make it a significant target for research in cancer biology and therapeutics.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ecotropic virus integration site 1 protein homolog; EVI-1; Histone-lysine N-methyltransferase MECOM; MDS1 and EVI1 complex locus protein; Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome-associated protein 1
基因别名: EVI1; MDS1; MECOM; PRDM3
Entrez Gene ID: (Human) 2122
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