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Invitrogen
MMP15 Polyclonal Antibody
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MMP15 Antibody (PA5-13184) in IHC (P)
Immunohistochemistry analysis of MMP15 in formalin-fixed and paraffin-embedded human colon carcinoma. Samples were incubated with MMP15 polyclonal antibody (Product # PA5-13184) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
产品信息
PA5-13184
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 165-194 amino acids from the N-terminal region of human MMP15
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Ammonium sulfate precipitation, Size-exclusion - Dialysis
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: matrix metallo protease; matrix metallopeptidase 15 (membrane-inserted); matrix metalloproteinase 15; matrix metalloproteinase 15 (membrane-inserted); Matrix metalloproteinase-15; Membrane type 2-MMP; Membrane-type matrix metalloproteinase 2; Membrane-type-2 matrix metalloproteinase; MMP; MMP-15; MMPs; MT-MMP 2; MT2-MMP; MT2MMP; MTMMP2; SMCP-2
基因别名: AI503551; MMP-15; MMP15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2
UniProt ID: (Human) P51511, (Mouse) O54732
Entrez Gene ID: (Human) 4324, (Mouse) 17388
