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Invitrogen
MMP15 (Cleaved Tyr132) Polyclonal Antibody
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MMP15 (Cleaved Tyr132) Antibody (PA5-76128) in WB
Western blot analysis of MMP15 in Lane 1: MCF-7 whole cell lysate (40 µg), Lane 2: SGC7901 whole cell lysate (40 µg), Lane 3: HCT116 whole cell lysate (40 µg), Lane 4: HEK293T whole cell lysate (40 µg). Samples were incubated with MMP15 polyclonal antibody (Product # PA5-76128) at a dilution of 1:500.
产品信息
PA5-76128
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 100-150 of Human MMP-15.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
MMP15 (matrix metallopeptidase 15), also known as MT2-MMP, is a member of the membrane-type matrix metalloproteinases characterized by their ability to degrade components of the extracellular matrix. It is encoded by the MMP15 gene, located on chromosome 16q12.2. Structurally, this enzyme is a type I transmembrane protein, composed of a signal peptide, a propeptide, a catalytic domain, a hemopexin-like domain, a transmembrane domain, and a cytoplasmic tail. The cleavage of the propeptide is crucial for its activation to degrade various substrates. The specific cleavage at Tyr132 is significant for its regulatory mechanisms in different physiological and pathological processes, including tissue remodeling, cancer progression, and metastasis. MMP15 has been implicated in cancer, where its expression levels correspond with the disease state and can influence cancer cell invasion and angiogenesis by modifying the extracellular environment and cellular interactions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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