Search
Invitrogen
Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8), Biotin
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 43
Phospho-Tau (Ser202, Thr205) Antibody (MN1020B) in WB
Molecular psychiatry 2024 -
Abeta ice reduces Tau pathology. A Representative images of AT8-Thioflavine S double labeling showing AT8-positive neurites surrounding an amyloid plaque (Thioflavine). B Representative images of AT8 immunolabeling showing neuritic plaques in the brain of APP swe /PS1 dE9 mice after PBS, Abeta wt or Abeta ice inoculation in the dentate gyrus. C Representative images of Tau-positive neuritic plaques in the h... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MN1020B
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Cat,
Chicken,
Ferret,
Fruit fly,
Hamster,
Horse,
Human,
Mammal,
Mouse,
Non-human primate,
Rabbit,
Rat,
Rhesus monkey
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
AT8
Immunogen
Partially purified human PHF-Tau (aa 202, 205).
Conjugate
Biotin
Biotin
Biotin
Form
Liquid
Concentration
0.1 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MN1020B targets PHF-tau (Ser202/Thr205) in IF, ELISA, and IHC (P) applications and shows reactivity with Human samples.
The MN1020B immunogen is partially purified human PHF-Tau.
MN1020B detects PHF-tau (Ser202/Thr205)a which has a predicted molecular weight of approximately 79 kDa.
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ31424; FTDP17; map tau; MGC138549; Microtubule-associated protein tau; microtubules; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; Paired helical filament-tau; PHF-tau; PHFtau; Tau-4; Tau5
Gene Aliases: MAPT; MAPTL; MTBT1; TAU
Entrez Gene ID: (Human) 4137
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support