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Fabgennix
MRP1 Polyclonal Antibody, FITC
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Product Details
MRP1-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to unique amino acid sequences on rat multidrug resistance-associated protein 1.
Conjugate
FITC
FITC
FITC
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC-transporter; MRP; ABCC1; ATP-binding cassette sub-family C ( CFTR/MRP) member 1a; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; ATP-binding cassette, sub-family C, member 1-like; ATP-binding cassette, subfamily C (CFTR/MRP), member 1; DKFZp686N04233; DKFZp781G125; glutathione-S-conjugate-translocating ATPase ABCC1; leuk; leukotriene C(4) transporter; LTC4 transporter; multidrug resistance protein 1; multidrug resistance-associated protein 1-like; multiple drug resistance-associated protein; unnamed protein product
Gene Aliases: Abcc1a; Abcc1b; Avcc1a; Mdrap; MRP; Mrp1
UniProt ID: (Rat) Q8CG09, (Mouse) O35379
Entrez Gene ID: (Rat) 24565, (Mouse) 17250
long-chain fatty acid transporter activity
ATP binding
xenobiotic-transporting ATPase activity
cobalamin-transporting ATPase activity
glutathione S-conjugate-exporting ATPase activity
efflux transmembrane transporter activity
oxidoreductase activity
ATPase activity
transmembrane transporter activity
lipid-transporting ATPase activity
glutathione transmembrane transporter activity
xenobiotic transporter activity
carboxylic acid transmembrane transporter activity
ABC-type transporter activity
tissue homeostasis
granuloma formation
inflammatory response to antigenic stimulus
endothelium development
leukotriene metabolic process
glutathione metabolic process
lipid transport
apoptotic process
inflammatory response
immune response
cellular response to DNA damage stimulus
response to oxidative stress
memory
glucocorticoid metabolic process
response to xenobiotic stimulus
response to toxic substance
glial cell differentiation
gene expression
monocarboxylic acid transport
bilirubin transport
cobalamin transport
plasma membrane long-chain fatty acid transport
leukotriene biosynthetic process
amygdala development
hippocampus development
neurogenesis
positive regulation of cell migration
phospholipid efflux
response to interferon-gamma
protein localization to cell surface
response to fluid shear stress
glutathione transport
glutathione transmembrane transport
multicellular organism growth
exploration behavior
macrophage activation
vasodilation
regulation of membrane potential
superoxide anion generation
xenobiotic transport
pigment accumulation
fibroblast apoptotic process
phospholipid translocation
cell redox homeostasis
tetrahydrobiopterin metabolic process
antigen processing and presentation of lipid antigen via MHC class Ib
astrocyte differentiation
beta-amyloid metabolic process
hydrogen peroxide biosynthetic process
positive regulation of inflammatory response
regulation of catalytic activity
defense response to Gram-positive bacterium
NK T cell activation
response to glucocorticoid
cellular chemical homeostasis
transmembrane transport
cell chemotaxis
transepithelial transport
cyclic nucleotide transport
cellular response to interferon-gamma
leukotriene transport
endothelial cell apoptotic process
lymphocyte migration
beta-amyloid clearance
neural tissue regeneration
regulation of blood vessel diameter
sphingolipid translocation
export across plasma membrane
export from cell
intracellular nitrogen homeostasis
reactive oxygen species biosynthetic process
cellular response to beta-amyloid
carboxylic acid transmembrane transport
drug transmembrane export
drug transport across blood-brain barrier
regulation of cellular response to drug
drug transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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