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Invitrogen
MSH2 Polyclonal Antibody
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MSH2 Antibody (PA5-79695) in ICC/IF
Immunocytochemistry analysis of MSH2 using anti-MSH2 antibody (Product # PA5-79695) . MSH2 was detected in a section of U2OS cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 2μg/mL rabbit anti-MSH2 antibody (Product # PA5-79695) overnight at 4°C. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visua... View More
产品信息
PA5-79695
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human MSH2 recombinant protein (Position: Q337-N583).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human K562 whole cell, human SH-SY5Y whole cell, human HEL whole cell, human 293T whole cell, human A549 whole cell, rat PC-12 whole cell, mouse Neuro-2a whole cell. IHC: Human Intestinal Cancer tissue. ICC/IF: U20S cell, SMMC cell. Flow: A431 cell.
靶标信息
Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA mismatch repair protein Msh2; hMSH2; mismatch repair protein; Msh2p; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2
基因别名: AI788990; COCA1; FCC1; HNPCC; HNPCC1; LCFS2; MSH2
UniProt ID: (Human) P43246, (Mouse) P43247, (Rat) P54275
Entrez Gene ID: (Human) 4436, (Mouse) 17685, (Rat) 81709
magnesium ion binding
four-way junction DNA binding
Y-form DNA binding
heteroduplex DNA loop binding
double-strand/single-strand DNA junction binding
DNA binding
double-stranded DNA binding
single-stranded DNA binding
protein binding
ATP binding
protein C-terminus binding
ATPase activity
centromeric DNA binding
enzyme binding
protein kinase binding
mismatched DNA binding
guanine/thymine mispair binding
dinucleotide insertion or deletion binding
single guanine insertion binding
single thymine insertion binding
dinucleotide repeat insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding
nucleotide binding
damaged DNA binding
DNA-dependent ATPase activity
single base insertion or deletion binding
DNA metabolism protein
meiotic mismatch repair
in utero embryonic development
oxidative phosphorylation
DNA repair
mismatch repair
postreplication repair
double-strand break repair
meiotic gene conversion
cell cycle arrest
reciprocal meiotic recombination
germ cell development
determination of adult lifespan
male gonad development
response to X-ray
response to UV-B
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
B cell mediated immunity
B cell differentiation
intra-S DNA damage checkpoint
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of neuron apoptotic process
maintenance of DNA repeat elements
negative regulation of reciprocal meiotic recombination
isotype switching
negative regulation of DNA recombination
positive regulation of helicase activity
somatic recombination of immunoglobulin genes involved in immune response
cellular response to DNA damage stimulus
cell cycle
intrinsic apoptotic signaling pathway in response to DNA damage
spermatogenesis
response to organic cyclic compound
response to drug
response to amino acid
