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NeoBiotechnologies
MSH6 (DNA Mismatch Repair Protein) Recombinant Rabbit Monoclonal Antibody (MSVA-906R)
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MSH6 (DNA Mismatch Repair Protein) Antibody (2956-RBM25-P1) in IHC (P)
DNA mismatch repair protein Msh6 Rabbit Recombinant Monoclonal Antibody (MSVA-906R) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
2956-RBM25-P1
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
MSVA-906R
Immunogen
Recombinant fragment (around aa 1-100) of human MSH6 protein (exact sequence is proprietary).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product cellular localization: Cell membrane, Early endosome membrane, Endomembrane system, Recycling endosome membrane.
Positive control: Alveolar macrophages, tonsil crypt epithelium and the placental cytotrophoblast show strong, predominantly membranous positivity. Follicle centre macrophages should show at least moderate intensity staining.
Tissue specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Target Information
The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G/T mismatch-binding protein; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; mutS protein homolog 6; mutS-alpha 160 kDa subunit; MutS-alpha 160kDa subunit; mutS-like protein 6; Sperm associated protein; sperm-associated protein; unnamed protein product
Gene Aliases: GTBP; GTMBP; HNPCC5; HSAP; LYNCH5; MMRCS3; MSH-6; p160
UniProt ID: (Human) P52701
Entrez Gene ID: (Human) 2956
magnesium ion binding
four-way junction DNA binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
protein binding
ATP binding
DNA-dependent ATPase activity
enzyme binding
mismatched DNA binding
guanine/thymine mispair binding
single guanine insertion binding
single thymine insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding
histone H3K36me3 reader activity
ATP-dependent DNA damage sensor activity
meiotic mismatch repair
DNA repair
mismatch repair
chromatin organization
spermatogenesis
determination of adult lifespan
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
maintenance of DNA repeat elements
isotype switching
negative regulation of DNA recombination
intrinsic apoptotic signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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