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Invitrogen
MYCT1 Polyclonal Antibody
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产品信息
PA5-34450
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 17 amino acid synthetic peptide near the carboxy terminus of human MYCT1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is rat lung tissue lysate.
PA5-34450 can be used with blocking peptide PEP-1492.
靶标信息
MYCT1 was initially identified as a novel target of the c-Myc oncogene in myeloid cells. It is a widely expressed nuclear protein whose overexpression can promote apoptosis, alteration of morphology, enhancement of anchorage-independent cell growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation. MYCT1 binds to the promoters of several c-Myc-regulated genes and it has been suggested that the phenotypes seen in MYCT1-overexpressing cells are a result of the deregulation of these genes. RUNX1-ETO, a fusion protein made up of RUNX1 and ETO, is thought to deregulate the proliferation and responsiveness of human hematopoietic progenitor cells downstream of MYCT1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MT-MC1; myc target in myeloid cells 1; Myc target in myeloid cells protein 1; Myc target protein 1
基因别名: 1110020B04Rik; AI225941; AI642973; MTLC; MTMC1; MYCT1
UniProt ID: (Human) Q8N699, (Mouse) Q8R411
Entrez Gene ID: (Human) 80177, (Mouse) 68632, (Rat) 292264
