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Invitrogen
NCoR1 Polyclonal Antibody
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产品信息
PA1-844A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
C. elegans,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues C P(2427) A P L L S A Q Y E T L S D S D D(2443) of mouse N-CoR.
偶联物
形式
Liquid
浓度
0.7 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-844A detects human and mouse nuclear receptor corepressor (N-CoR).
PA1-844A has been successfully used in Western blot, ICC/IF, IHC (P) and immunoprecipitation (ChIP) procedures. By Western blot, this antibody detects a protein at ~270 kDa representing N-CoR from HeLa cell extracts and mouse RAW 264.7/primary macrophages. This antibody is not recommended for mouse C2C12 cells in immunofluorescent applications.
The PA1-844A immunogen is a synthetic peptide corresponding to residues C P(2427) A P L L S A Q Y E T L S D S D D(2443) of mouse N-CoR. This immunizing peptide (Cat. # PEP-061) is available for use in neutralization and control experiments.
靶标信息
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: h KIAA1047; hCIT529I10; MGC104216; N-CoR; N-CoR1; nuclear receptor corepressor; Nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; retinoid X receptor interacting protein 13; retinoid X receptor-interacting protein 13; thyroid hormone- and retinoic acid receptor-associated corepressor 1
基因别名: 5730405M06Rik; A230020K14Rik; hN-CoR; KIAA1047; mKIAA1047; N-CoR; N-CoR1; NCOR1; PPP1R109; RIP13; Rxrip13; TRAC1
UniProt ID: (Human) O75376
Entrez Gene ID: (Human) 9611, (Mouse) 20185
RNA polymerase II regulatory region DNA binding
RNA polymerase II activating transcription factor binding
chromatin binding
transcription corepressor activity
protein binding
ligand-dependent nuclear receptor binding
protein domain specific binding
estrogen receptor binding
nuclear hormone receptor binding
histone deacetylase binding
peroxisome proliferator activated receptor binding
transcription regulatory region DNA binding
retinoid X receptor binding
thyroid hormone receptor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
histone deacetylase regulator activity
retinoic acid receptor binding
sequence-specific DNA binding
chromatin/chromatin-binding, or -regulatory protein
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
skeletal muscle tissue development
lactation
circadian rhythm
positive regulation of cell proliferation
covalent chromatin modification
cerebellum development
cellular lipid metabolic process
negative regulation of JNK cascade
spindle assembly
regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
negative regulation of production of miRNAs involved in gene silencing by miRNA
regulation of fatty acid transport
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
negative regulation of gene expression
negative regulation of phosphatidylinositol 3-kinase signaling
chromatin modification
thalamus development
regulation of histone deacetylation
positive regulation of histone deacetylation
circadian regulation of gene expression
regulation of multicellular organism growth
cholesterol homeostasis
negative regulation of transcription, DNA-templated
regulation of catalytic activity
definitive erythrocyte differentiation
