Invitrogen

NGFR Monoclonal Antibody (NGFR5)

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4个已发表图片
20 篇参考文献
查看其他72个NGFR (CD271)抗体

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说明书
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NGFR Monoclonal Antibody (NGFR5)

产品信息

MA5-13314

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:10-1:200
-

免疫组化 (IHC)

-
查看12篇已发表文章 12篇已发表文章

免疫细胞化学 (ICC/IF)

1:10-1:200
查看4篇已发表文章 4篇已发表文章

流式细胞分析 (Flow)

2 µg/test
查看2篇已发表文章 2篇已发表文章

免疫沉淀 (IP)

-
查看1篇已发表文章 1篇已发表文章

其他PubMed (Misc)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Cat, Ferret, Human, Non-human primate, Rabbit, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

NGFR5

抗原

NGFR from A875 melanoma cells
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10982037

产品详细信息

MA5-13314 targets Neurotrophin Receptor /NGF-Receptor (p75NGFR) in FACS, ICC/IF and WB applications and shows reactivity with Feline, Ferret, Human, Rat, Non-human primate, and Rabbit samples. This antibody does not react with rat tissue in Western blot applications.

The MA5-13314 immunogen is nGFR from A875 melanoma cells.

靶标信息

Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; p-75; p75 ICD; p75 ntr; TNFR superfamily, member 16; TNR16; Tumor necrosis factor receptor superfamily member 16

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基因别名: CD271; Gp80-LNGFR; LNGFR; NGFR; p75; p75(NTR); p75NTR; RNNGFRR; TNFRSF16

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UniProt ID: (Human) P08138, (Rat) P07174

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Entrez Gene ID: (Human) 4804, (Rabbit) 100349095, (Rat) 24596

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功能
beta-amyloid binding signal transducer activity receptor activity transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity neurotrophin TRKA receptor binding protein binding Rab GTPase binding ubiquitin protein ligase binding nerve growth factor binding preprotein binding death receptor activity neurotrophin binding transmembrane signal receptor
参与通路
intracellular protein transport activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response immune response axon guidance response to wounding negative regulation of neuron projection development sensory perception of pain membrane protein intracellular domain proteolysis positive regulation of myelination positive regulation of synaptic transmission, cholinergic response to lipopolysaccharide circadian regulation of gene expression tumor necrosis factor-mediated signaling pathway cellular response to oxidative stress positive regulation of Rho protein signal transduction skeletal muscle cell differentiation regulation of cell proliferation glucose homeostasis regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process neurotrophin TRK receptor signaling pathway negative regulation of axonogenesis positive regulation of axonogenesis positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization positive regulation of synaptic transmission, glutamatergic apoptotic signaling pathway positive regulation of neuron death regulation of reactive oxygen species metabolic process regulation of glucose import in response to insulin stimulus apoptotic process signal transduction central nervous system development regulation of gene expression positive regulation of cell death programmed cell death detection of temperature stimulus nerve development hair follicle morphogenesis negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of odontogenesis of dentin-containing tooth skin development positive regulation of fibroblast proliferation negative regulation of hair follicle development negative regulation of cell death positive regulation of apoptotic signaling pathway
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