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NNT1 Polyclonal Antibody
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FIGURE: 1 / 1
NNT1 Antibody (PA5-59980) in WB
Western blot analysis of NNT1 in control (vector only transfected HEK293T lysate) and CLCF1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells). Samples were probed using a NNT1 Polyclonal Antibody (Product # PA5-59980).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-59980
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NNT1. Recombinant protein control fragment (Product #RP-91951).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KTYDLTRYLE HQLRSLAGTY LNYLGPPFNE PDFNPPRLGA ETLPRATVDL EVWRSLNDKL RLTQNYE
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
Target Information
NNT-1/BCSF-3 is a neurotrophic factor with B-cell-stimulating capabilities. Expressed in the lymph nodes and spleen, NNT-1/BCSF-3 activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member b (LIFR-b) by binding and inducing the tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss, and B cell hyperplasia associated with increases in serum IgG and IgM.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell stimulatory factor 3; B-cell-stimulating factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; novel neurotrophin-1; unnamed protein product
Gene Aliases: BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6
UniProt ID: (Human) Q9UBD9
Entrez Gene ID: (Human) 23529
positive regulation of immunoglobulin production
cell surface receptor signaling pathway
JAK-STAT cascade
positive regulation of cell proliferation
cytokine-mediated signaling pathway
B cell differentiation
positive regulation of B cell proliferation
negative regulation of neuron apoptotic process
positive regulation of isotype switching to IgE isotypes
positive regulation of astrocyte differentiation
receptor signaling pathway via STAT
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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