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Invitrogen
NR5A1 Monoclonal Antibody (N1665)
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NR5A1 Antibody (434200) in WB
Western blot was performed using NR5A1 Monoclonal Antibody (Product # 434200) and a 50 kDa band corresponding to NR5A1 was observed in the cell line and tissues tested. Modified whole cell extracts (1% SDS) (30 µg lysate) of Hep G2 (Lane 1), Hek-293 (Lane 2), tissue extracts of Mouse Ovary (Lane 3), Mouse Heart (Lane 4) and Mouse Prostate (Lane 5) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blo... View More
产品信息
434200
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N1665
抗原
BALB/c mouse immunized with E.coli-expressed recombinant human SF-1 (218-461aa).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
physiological saline
内含物
0.1% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody specifically recognizes human SF-1 and cross reacts with mouse and rat SF-1.
靶标信息
Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor involved in organ development and differentiation of the endocrine system. SF-1 has been shown to be essential for fetal development of the hypothalamus, pituitary gland, gonads, and the adrenal gland. SF-1 has been shown to promote transcriptional activity of many steroidogenic enzymes from the cytochrome P450 family. SF-1 contains two activation function domains, designated AF1 and AF2, common to many nuclear steroid receptors which have been shown to be necessary for interaction with other nuclear receptors as well as coactivators and corepressors including steroid receptor coactivator-1 (SRC-1), glucocorticoid receptor interacting protein 1 (GRIP1), cAMP response element binding protein (CREB) binding protein (CBP) and silencing mediator of retinoid acid and thyroid hormone receptor (SMRT).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: adrenal 4 binding protein; Adrenal 4 binding protein (AD4BP); Adrenal 4-binding protein; ELP; Embryonal long terminal repeat-binding protein; Embryonal LTR-binding protein; fushi tarazu 1 factor homolog; Fushi tarazu factor homolog 1; Fushi tarazu factor homolog 1 (FTZ1); nuclear receptor AdBP4; Nuclear receptor subfamily 5 group A member 1; Nuclear receptor subfamily 5 group A member 1 (NR5A1); nuclear receptor subfamily 5, group A, member 1; SF-1; Steroid hormone receptor Ad4BP; Steroid hydroxylase positive regulator; Steroidogenic factor 1; Steroidogenic factor 1 (SF1); steroidogenic factor 1 nuclear receptor; steroidogenic factor-1; STF-1; STF1
基因别名: AD4BP; Ad4BP/SF-1; ELP; ELP-3; Ftz-F1; FTZ1; FTZF1; hSF-1; NR5A1; POF7; SF-1; SF1; SPGF8; SRXY3
UniProt ID: (Human) Q13285, (Mouse) P33242, (Rat) P50569
Entrez Gene ID: (Human) 2516, (Mouse) 26423, (Rat) 83826
transcription regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
phospholipid binding
zinc ion binding
enzyme binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
lipid binding
sequence-specific DNA binding
metal ion binding
C4 zinc finger nuclear receptor
luteinization
transcription initiation from RNA polymerase II promoter
cell-cell signaling
primary sex determination
male gonad development
hormone-mediated signaling pathway
tissue development
multicellular organism aging
cell differentiation
adrenal gland development
intracellular receptor signaling pathway
hormone metabolic process
steroid hormone mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
regulation of steroid biosynthetic process
maintenance of protein location in nucleus
positive regulation of male gonad development
negative regulation of female gonad development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
reproductive process
positive regulation of transcription, DNA-templated
female gonad development
