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Alomone Labs, LTD

NRG1 Type III (extracellular) Polyclonal Antibody

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NRG1 Type III (extracellular) Polyclonal Antibody

产品信息

ANR-113-200UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)DKIFEYDSPTHLD, corresponding to amino acid residues 101-113 of human Neuregulin-1 Type III, Extracellular
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

靶标信息

Neuregulin-1 (Nrg1)/erbB signaling regulates neuronal development, migration, myelination, and synaptic maintenance. The expression of NRG1 type III expression have been studied in the adult brain, the medial prefrontal cortex, ventral hippocampus, and ventral subiculum. Expression of NRG1 type III expressio in these regions are involved in the regulation of sensorimotor gating and short-term memory.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: acetylcholine receptor-inducing activity; glial growth factor 2; growth factor; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); III Type NRG1; neu differentiation factor; neuregulin 1; neuregulin 1 type III beta 3; Neuregulin-1 Type III; NRG-1 Type III; NRG1; NRG1 class VII isoform alpha 2a; NRG1 class VII isoform alpha 2b; NRG1 class VII isoform alpha beta 2a; NRG1 class VII isoform alpha beta 3; NRG1 class VII isoform beta 2a; NRG1 class VII isoform beta 3; NRG1 Type 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; type I neuregulin 1; type III neuregulin 1; unnamed protein product

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基因别名: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF

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UniProt ID: (Human) Q02297, (Mouse) Q6DR98

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Entrez Gene ID: (Human) 3084, (Rat) 112400, (Mouse) 211323

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功能
transcription cofactor activity receptor binding cytokine activity integrin binding protein binding growth factor activity zinc ion binding nickel cation binding protein tyrosine kinase activator activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity receptor agonist activity ErbB-2 class receptor binding growth factor
参与通路
ventricular trabecula myocardium morphogenesis cell communication transmembrane receptor protein tyrosine kinase signaling pathway nervous system development brain development peripheral nervous system development cell proliferation positive regulation of cell proliferation regulation of cell communication negative regulation of cardiac muscle cell apoptotic process neural crest cell development regulation of signaling cell differentiation positive regulation of cell growth mammary gland development positive regulation of protein complex assembly activation of protein kinase B activity intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway ERBB3 signaling pathway ERBB4 signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-ERBB4 signaling pathway ERBB4-ERBB4 signaling pathway wound healing positive regulation of cell adhesion negative regulation of transcription, DNA-templated negative chemotaxis negative regulation of secretion positive regulation of developmental process positive regulation of striated muscle cell differentiation cardiac muscle cell differentiation ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation cardiac muscle cell myoblast differentiation endocardial cell differentiation regulation of biological quality positive regulation of ERK1 and ERK2 cascade regulation of postsynaptic neurotransmitter receptor internalization positive regulation of peptidyl-tyrosine autophosphorylation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand MAPK cascade cell morphogenesis cardiac conduction system development activation of transmembrane receptor protein tyrosine kinase activity synapse assembly heart development muscle organ development locomotory behavior regulation of blood pressure glial cell differentiation glucose transport cell migration glial cell fate commitment negative regulation of protein catabolic process myelination regulation of protein heterodimerization activity cellular protein complex disassembly neurotransmitter receptor metabolic process regulation of cell differentiation positive regulation of protein kinase activity positive regulation of Ras protein signal transduction animal organ development neuron fate commitment positive regulation of protein kinase B signaling positive regulation of protein tyrosine kinase activity positive regulation of calcineurin-NFAT signaling cascade positive regulation of cardiac muscle cell differentiation axon ensheathment positive regulation of myelination oligodendrocyte differentiation
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