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Positive test controls include: HeLa, 293T, A-549, Raji, B cells, Mouse brain, Mouse kidney. The target is usually found in the following locations: Lysosome membrane, Single-pass type I membrane protein.
Immunogen sequence: ALPFGSSPHR VFHDLLSEQQ LLEVEDLSLS LLQGGGLGPL SLPPDLPDLD PECRELLLDF ANSSAELTGC LVRSARPVRL CQTCYPLFQQ VVSKMDNISR AAGNTSESQS CARSLLMADR MQIVVILSEF FNTTWQEANC ANCLTNNSEE LSNSTVYFLN LFNHTLTCFE HNLQGNAHSL LQTKNYSEVC KNCREAYKTL SSLYSEMQKM NELENKAEPG THLCIDVEDA MNITRKLWSR TFNCSVPCSD TVP
This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Chloride channel 7 beta subunit; CLCN7 accessory beta subunit; GAIP-interacting protein N terminus; grey lethal osteopetrosis; grey-lethal osteopetrosis; Grey-lethal protein; Osteopetrosis-associated transmembrane protein 1
基因别名: 1200002H13Rik; GIPN; GL; HSPC019; OPTB5; OSTM1; UNQ6098/PRO21201
UniProt ID: (Human) Q86WC4, (Mouse) Q8BGT0
Entrez Gene ID: (Human) 28962, (Mouse) 14628