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          • Primary Antibodies ›
          • Amyloid Oligomers Antibodies

          Invitrogen

          Oligomer A11 Polyclonal Antibody

          12个已发表图片
          123 篇参考文献
          查看其他2个Amyloid Oligomers抗体

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          Cite Oligomer A11 Polyclonal Antibody

          Additional Information:
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          • 抗体检测数据 (1)
          • 已发表图片 (12)
          Oligomer A11 Antibody in Western Blot (WB)
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          Oligomer A11 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          图: 1 / 13

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          Oligomer A11 Antibody (AHB0052) in WB

          Rabbit Anti-Oligomer (A11) Polyclonal Antibody. 1 µg of soluble Abeta42 monomers, Abeta42 oligomers, Ab42 fibrils, IAPP oligomers and alpha-Synuclein oligomers was applied to a nitrocellulose membrane and probed with Rabbit Anti-oligomer (A11) polyclonal antibody (top row; Product # AHB0052) or with 6E10 (bottom row, Product # 44-352). Anti-oligomer antibody recognizes all types of oligomers, but not monomers or fibrils. 6E10 recognizes all species of Abeta without regard to conformation, but not IAPP or alpha-Synuclein. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

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          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in Immunohistochemistry (PFA fixed), Immunocytochemistry (IHC (PFA), ICC/IF)
          Oligomer A11 Antibody in Immunohistochemistry (Frozen) (IHC (F))
          Oligomer A11 Antibody in Immunohistochemistry (IHC)
          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in ELISA (ELISA)
          Oligomer A11 Antibody in Dot Blot (DB)
          Oligomer A11 Antibody in Dot Blot (DB)
          Oligomer A11 Antibody in Dot Blot (DB)

          产品信息

          AHB0052

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          Assay-dependent
          查看33篇已发表文章 33篇已发表文章

          免疫组化 (IHC)

          1-5 µg/mL
          查看18篇已发表文章 18篇已发表文章

          免疫组织化学(多聚甲醛固定) (IHC (PFA))

          -
          查看1篇已发表文章 1篇已发表文章

          免疫组化(冰冻) (IHC (F))

          -
          查看1篇已发表文章 1篇已发表文章

          免疫组织化学(悬浮细胞) (IHC (Free))

          -
          查看1篇已发表文章 1篇已发表文章

          免疫细胞化学 (ICC/IF)

          -
          查看16篇已发表文章 16篇已发表文章

          流式细胞分析 (Flow)

          -
          查看1篇已发表文章 1篇已发表文章

          酶联免疫吸附实验 (ELISA)

          0.1-1 µg/mL
          查看5篇已发表文章 5篇已发表文章

          免疫沉淀 (IP)

          -
          查看2篇已发表文章 2篇已发表文章

          中和实验 (Neu)

          Assay-dependent
          查看1篇已发表文章 1篇已发表文章

          点杂交 (DB)

          0.1-1 µg/mL
          查看33篇已发表文章 33篇已发表文章

          其他PubMed (Misc)

          -
          查看11篇已发表文章 11篇已发表文章
          产品规格

          种属反应

          Human, Mouse, Rat

          已发表种属

          Bacteria, Cat, Cynomolgus monkey, Fruit fly, Human, Mouse, Nematode, Rat, Zebrafish

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Synthetic molecular mimic of soluble oligomers.

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1.0 mg/mL

          规格

          50 µg

          纯化类型

          purified

          保存液

          PBS, pH 7.4

          内含物

          0.1% sodium azide

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_10376183

          产品详细信息

          This antibody recognizes amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. A11 reacts with soluble AB42 oligomers and does not react with soluble low molecular weight AB40 or AB40 fibrils. A11 recognizes oligomeric species of several other amyloidogenic polypeptides including AB42, human insulin, prion, polyglutamine, lysozyme, alpha-synuclein and yeast prion Sup35.

          Oligomeric AB42 is recommended as a positive control, monomeric and fibrillar AB42 as negative controls.

          靶标信息

          Amyloid beta oligomers are aggregates of the amyloid beta peptide, which is derived from the amyloid precursor protein (APP) through enzymatic cleavage. These oligomers are considered to be neurotoxic and have been implicated in the pathogenesis of Alzheimer's disease. Structurally, these oligomers can vary in size and form, ranging from dimers to large aggregates, and their formation is influenced by factors such as the peptide concentration, pH, and presence of metals. Functionally, these oligomers disrupt cellular processes, leading to synaptic dysfunction, oxidative stress, and ultimately neuronal death. They exert their toxic effects by interacting with cell membranes, forming pores, and triggering intracellular signaling pathways that result in neurodegeneration. The exact mechanisms by which Amyloid beta oligomers contribute to Alzheimer's disease are still under investigation, but they are a key focus of therapeutic strategies aimed at mitigating the progression of the disease.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          生物信息学

          蛋白别名: ABPP; AG; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; amyloid A4; amyloid beta; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid beta precursor protein (ABPP); amyloid beta protein; amyloid beta-protein precursor; Amyloid precursor protein; amyloid protein; Amyloid-beta (A4) precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloidogenic glycoprotein; APP; APPI; appican; beta-amyloid A4; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; Cerebral vascular amyloid peptide; CVAP; peptidase nexin-II; PN-II; PreA4; protease nexin II; Protease nexin-II; testicular tissue protein Li 2; unnamed protein product

          查看更多 收起

          基因别名: A4; AAA; ABETA; ABPP; AD1; Adap; Ag; alpha-sAPP; APP; APPI; betaApp; CTFgamma; CVAP; E030013M08Rik; PN-II; PN2; preA4

          查看更多 收起

          UniProt ID: (Human) B2R5V1, (Rat) P08592, (Mouse) P12023

          查看更多 收起

          Entrez Gene ID: (Human) 351, (Rat) 54226, (Mouse) 11820

          查看更多 收起

          功能
          G-protein coupled receptor binding DNA binding chromatin binding serine-type endopeptidase inhibitor activity receptor binding frizzled binding insulin receptor binding integrin binding protein binding heparin binding peptidase activator activity enzyme binding peptidase inhibitor activity receptor activator activity acetylcholine receptor activator activity acetylcholine receptor binding apolipoprotein binding chemoattractant activity identical protein binding protein homodimerization activity heparan sulfate proteoglycan binding metal ion binding ephrin receptor binding transition metal ion binding protein heterodimerization activity receptor agonist activity low-density lipoprotein particle receptor binding RAGE receptor binding chaperone binding PTB domain binding growth factor receptor binding amylin binding protein serine/threonine kinase binding molecular function activator activity heparan sulfate binding protease inhibitor
          参与通路
          negative regulation of transcription from RNA polymerase II promoter microglial cell activation response to yeast astrocyte activation involved in immune response regulation of transcription from RNA polymerase II promoter regulation of translation cellular copper ion homeostasis endocytosis apoptotic process cell adhesion G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Notch signaling pathway chemical synaptic transmission axonogenesis central nervous system development learning or memory learning memory mating behavior locomotory behavior axo-dendritic transport negative regulation of cell proliferation associative learning adult locomotory behavior visual learning response to lead ion regulation of gene expression positive regulation of macromolecule metabolic process positive regulation of gene expression negative regulation of gene expression response to auditory stimulus microglia development axon midline choice point recognition neuron remodeling dendrite development calcium-mediated signaling antibacterial humoral response antifungal humoral response regulation of Wnt signaling pathway extracellular matrix organization neuron projection development phospholipase D-activating G-protein coupled receptor signaling pathway positive regulation of chemokine production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of superoxide anion generation regulation of toll-like receptor signaling pathway ionotropic glutamate receptor signaling pathway regulation of multicellular organism growth lipoprotein metabolic process positive regulation of apoptotic process positive regulation of MAPK cascade positive regulation of neuron apoptotic process innate immune response positive regulation of nitric oxide biosynthetic process positive regulation of neuron differentiation positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of Toll signaling pathway positive regulation of glycolytic process positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade astrocyte activation regulation of long-term neuronal synaptic plasticity collateral sprouting in absence of injury positive regulation of inflammatory response regulation of synapse structure or activity synapse organization defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of calcium-mediated signaling positive regulation of cell activation cognition positive chemotaxis positive regulation of membrane protein ectodomain proteolysis regulation of protein metabolic process positive regulation of protein metabolic process protein homooligomerization protein tetramerization regulation of neurotransmitter uptake positive regulation of protein kinase B signaling low-density lipoprotein particle mediated signaling antimicrobial humoral immune response mediated by antimicrobial peptide protein trimerization positive regulation of ERK1 and ERK2 cascade response to interleukin-1 cellular response to copper ion cellular response to manganese ion cellular response to cAMP cellular response to norepinephrine stimulus positive regulation of monocyte chemotaxis negative regulation of canonical Wnt signaling pathway modulation of excitatory postsynaptic potential NMDA selective glutamate receptor signaling pathway positive regulation of gene expression, epigenetic positive regulation of cAMP/PKA signal transduction regulation of spontaneous synaptic transmission negative regulation of protein localization to nucleus regulation of beta-amyloid clearance negative regulation of long-term synaptic potentiation positive regulation of long-term synaptic potentiation positive regulation of NIK/NF-kappaB signaling regulation of calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of dendritic spine maintenance positive regulation of amyloid precursor protein catabolic process regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of blood circulation positive regulation of G protein-coupled receptor internalization positive regulation of endothelin production positive regulation of protein import cellular response to beta-amyloid regulation of presynapse assembly positive regulation of response to endoplasmic reticulum stress regulation of amyloid fibril formation positive regulation of amyloid fibril formation regulation of response to calcium ion amyloid fibril formation cellular response to nerve growth factor stimulus neuron projection maintenance positive regulation of T cell migration positive regulation of excitatory postsynaptic potential positive regulation of extrinsic apoptotic signaling pathway suckling behavior mRNA polyadenylation protein phosphorylation response to oxidative stress regulation of epidermal growth factor-activated receptor activity cholesterol metabolic process negative regulation of endopeptidase activity positive regulation of peptidase activity positive regulation of G2/M transition of mitotic cell cycle forebrain development regulation of protein binding negative regulation of neuron differentiation neuromuscular process controlling balance synaptic growth at neuromuscular junction neuron apoptotic process smooth endoplasmic reticulum calcium ion homeostasis nervous system development negative regulation of peptidase activity
          It has to be done as per old AB suggested Products section.

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