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Invitrogen
Oligomer A11 Polyclonal Antibody
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Oligomer A11 Antibody (AHB0052) in WB
Rabbit Anti-Oligomer (A11) Polyclonal Antibody. 1 µg of soluble Abeta42 monomers, Abeta42 oligomers, Ab42 fibrils, IAPP oligomers and alpha-Synuclein oligomers was applied to a nitrocellulose membrane and probed with Rabbit Anti-oligomer (A11) polyclonal antibody (top row; Product # AHB0052) or with 6E10 (bottom row, Product # 44-352). Anti-oligomer antibody recognizes all types of oligomers, but not monomers or fibrils. 6E10 recognizes all species of Abeta without regard to conformation, but not IAPP or alpha-Synuclein.
产品信息
AHB0052
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Bacteria,
C. elegans,
Cat,
Cynomolgus monkey,
Fruit fly,
Human,
Mouse,
Nematode,
Rat,
Zebrafish
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic molecular mimic of soluble oligomers.
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
purified
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. A11 reacts with soluble AB42 oligomers and does not react with soluble low molecular weight AB40 or AB40 fibrils. A11 recognizes oligomeric species of several other amyloidogenic polypeptides including AB42, human insulin, prion, polyglutamine, lysozyme, alpha-synuclein and yeast prion Sup35.
Oligomeric AB42 is recommended as a positive control, monomeric and fibrillar AB42 as negative controls.
靶标信息
Many degenerative diseases are known to be related to the accumulation of misfolded proteins called, amyloid fibrils. Soluble amyloid oligomers are considered as the principal pathogenic species which play an important role in the formation of amyloid fibrils; therefore, oligomers are involved in the pathogenesis of the many neurodegenerative diseases. This anti-oligomer antibody provides a facile means of assessing the significance of oligomers in disease pathogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Antioligomer A11; Insulin; Insulin-1; preproinsulin; proinsulin
基因别名: IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins1; Ins2-rs1; IRDN; MODY10
UniProt ID: (Human) P01308, (Rat) P01322, (Mouse) P01325
Entrez Gene ID: (Human) 3630, (Rat) 24505, (Mouse) 16333
MAPK cascade
negative regulation of acute inflammatory response
glucose metabolic process
regulation of transcription, DNA-templated
regulation of cellular amino acid metabolic process
ER to Golgi vesicle-mediated transport
acute-phase response
G-protein coupled receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
insulin receptor signaling pathway
positive regulation of gene expression
positive regulation of phosphatidylinositol 3-kinase signaling
glucose transport
regulation of transmembrane transporter activity
positive regulation of cell growth
positive regulation of cell migration
positive regulation of protein autophosphorylation
activation of protein kinase B activity
positive regulation of cellular protein metabolic process
negative regulation of protein oligomerization
regulation of protein localization
negative regulation of NAD(P)H oxidase activity
wound healing
negative regulation of protein catabolic process
glucose homeostasis
positive regulation of MAPK cascade
cellular protein metabolic process
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
negative regulation of gluconeogenesis
positive regulation of glycogen biosynthetic process
positive regulation of DNA replication
negative regulation of glycogen catabolic process
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
negative regulation of proteolysis
negative regulation of vasodilation
positive regulation of vasodilation
negative regulation of fatty acid metabolic process
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
alpha-beta T cell activation
positive regulation of lipid biosynthetic process
regulation of protein secretion
negative regulation of protein secretion
positive regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of lipid catabolic process
positive regulation of nitric-oxide synthase activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein kinase B signaling
fatty acid homeostasis
negative regulation of respiratory burst involved in inflammatory response
positive regulation of respiratory burst
positive regulation of peptide hormone secretion
positive regulation of brown fat cell differentiation
positive regulation of protein localization to nucleus
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of feeding behavior
response to organic substance
response to cytokine
response to peptide hormone
response to cAMP
carbohydrate metabolic process
