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Alomone Labs, LTD

P2X4 Receptor Polyclonal Antibody

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P2X4 Receptor Polyclonal Antibody

Product Details

APR-002-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (IHC)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)KKYKYVEDYEQGLSGEMNQ, corresponding to amino acid residues 370-388 of rat P2X4 receptor, Intracellular, C-terminus
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL once reconstituted

Amount

160 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP receptor; ATP receptor P2X4 subunit isoform c; ionotropic purinergic 4; ATP-gated cation channel protein; ionotropic ATP receptor subtype; ionotropic purinergic receptor; ligand gated ion channel; P2X receptor, subunit 4; P2X4; P2X4a; purinergic receptor P2X, ligand gated ion channel, 4; purinergic receptor P2X, ligand-gated ion channel 4; purinergic receptor P2X4; purinoceptor P2X4; unnamed protein product

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Gene Aliases: D5Ertd444e; P2X4; P2X4R

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UniProt ID: (Human) Q99571, (Rat) P51577

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Entrez Gene ID: (Human) 5025, (Mouse) 18438, (Rat) 29659

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Function(s)
purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding ion channel activity copper ion binding protein binding ATP binding zinc ion binding identical protein binding cadherin binding ligand-gated calcium channel activity ligand-gated ion channel activity ATP-gated ion channel activity ligand-gated monoatomic cation channel activity
Process(es)
regulation of sodium ion transport response to ischemia nitric oxide biosynthetic process ion transport cation transport calcium ion transport signal transduction regulation of blood pressure positive regulation of calcium ion transport into cytosol negative regulation of cardiac muscle hypertrophy neuronal action potential sensory perception of pain calcium-mediated signaling response to ATP ion transmembrane transport response to fluid shear stress purinergic nucleotide receptor signaling pathway vasodilation positive regulation of blood vessel endothelial cell migration behavioral response to pain response to axon injury positive regulation of calcium-mediated signaling regulation of chemotaxis sensory perception of touch positive regulation of protein kinase B signaling membrane depolarization regulation of cardiac muscle contraction relaxation of cardiac muscle excitatory postsynaptic potential calcium ion transmembrane transport cellular response to zinc ion cellular response to ATP apoptotic signaling pathway cation transmembrane transport positive regulation of microglial cell migration positive regulation of endothelial cell chemotaxis tissue homeostasis response to stress regulation of metal ion transport positive regulation of cell migration positive regulation of prostaglandin secretion endothelial cell activation positive regulation of nitric oxide biosynthetic process positive regulation of calcium ion transport regulation of ruffle assembly positive regulation of intracellular signal transduction
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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