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Invitrogen
PAM Polyclonal Antibody
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产品信息
PA5-115606
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MYCBP2(Accession O75592), corresponding to amino acid residues S979-E1029.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total MYCBP2.
靶标信息
This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase MYCBP2; Highwire; Myc-binding protein 2; mycbp2; pam, highwire, rpm 1; Pam/highwire/rpm-1 protein; probable E3 ubiquitin-protein ligase MYCBP2; Protein associated with Myc; Protein Magellan
基因别名: AU023734; AW107953; AW546647; C130061D10Rik; KIAA0916; Myc-bp2; MYCBP2; PAM; Phr; Phr1; R75243
UniProt ID: (Human) O75592, (Mouse) Q7TPH6
Entrez Gene ID: (Human) 23077, (Rat) 290447, (Mouse) 105689
protein binding
zinc ion binding
ligase activity
ubiquitin-protein transferase activity
protein homodimerization activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
guanyl-nucleotide exchange factor
ubiquitin-protein ligase
protein modifying enzyme
transcription, DNA-templated
regulation of transcription, DNA-templated
protein ubiquitination
motor neuron axon guidance
branchiomotor neuron axon guidance
central nervous system projection neuron axonogenesis
regulation of protein localization
negative regulation of protein catabolic process
cell morphogenesis involved in neuron differentiation
regulation of cytoskeleton organization
