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Invitrogen
PBX1 Polyclonal Antibody
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产品信息
PA5-82100
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PRLMHSHAGV GMAGHPGLSQ HLQDGAGGTE GEGGRKQDIG DILQQIMTIT DQSLDEAQAR KHALNCHRMK PALFNVLCEI KEKTVLSIRG AQEEEPTDPQ LMRLDNMLLA EGV
Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 77%.
靶标信息
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1; 19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; OTTHUMP00000032205; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1
基因别名: 2310056B04Rik; D230003C07Rik; Pbx-1; PBX1; PRL
UniProt ID: (Human) P40424, (Mouse) P41778
Entrez Gene ID: (Human) 5087, (Mouse) 18514, (Rat) 304947
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein heterodimerization activity
transcription factor binding
sequence-specific DNA binding
molecular_function
homeodomain transcription factor
branching involved in ureteric bud morphogenesis
transcription from RNA polymerase II promoter
steroid biosynthetic process
sex differentiation
positive regulation of cell proliferation
anterior/posterior pattern specification
proximal/distal pattern formation
positive regulation of G2/M transition of mitotic cell cycle
regulation of ossification
adrenal gland development
embryonic limb morphogenesis
somatic stem cell population maintenance
embryonic hemopoiesis
negative regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
spleen development
thymus development
embryonic skeletal system development
urogenital system development
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
organ morphogenesis
cell differentiation
regulation of cell proliferation
negative regulation of sequence-specific DNA binding transcription factor activity
embryonic organ development
biological_process
